Lakshmaiah Kc, Guruprasad B, Purohit Samit, Rao Sandesh, Bishwas Siddhartha, Lokanath D
Kidwai Memorial Institute of Oncology, Dr. M.H. Marigowda Road, Bangalore 560029, Karnataka, India.
Ecancermedicalscience. 2013 Jul 3;7:330. doi: 10.3332/ecancer.2013.330. Print 2013.
Primary non-Hodgkin's lymphoma of bone (PNHLB) accounts for less than 5% of all primary bone tumours and less than 1% of all non-Hodgkin's lymphoma. Due to its rarity, only a few retrospective studies have been published describing the prognosis and its treatment. We report our experience of 20 cases of PNHLB with their clinicopathologic correlation that were treated at our centre over a period of ten years. There were 16 cases of the mono-ostotic subtype and four cases of poly-ostotic subtype. All of these had a histological diagnosis of diffuse large B-cell lymphoma. The age of presentation was fifth to sixth decade. The mono-ostotic subtype commonly presented with the involvement of femur or humerus, while the poly-ostotic subtype commonly had paraparesis due to vertebral involvement. Cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)-based chemotherapy was given to all patients, but definitive radiotherapy was used only in the mono-ostotic subtype. At median follow-up of 38 months (range 5-96 months), event-free survival was 81% and 25% with mono-ostotic and poly-ostotic subtypes, respectively. Thus poly-ostotic PNHLB is a distinctive entity with a poor prognosis, and larger studies are needed for better management of this subtype.
原发性骨非霍奇金淋巴瘤（PNHLB）占所有原发性骨肿瘤的比例不到5%，占所有非霍奇金淋巴瘤的比例不到1%。由于其罕见性，仅有少数回顾性研究发表，描述其预后及治疗情况。我们报告了在我们中心十年间治疗的20例PNHLB患者的经验及其临床病理相关性。其中单骨型亚型16例，多骨型亚型4例。所有病例的组织学诊断均为弥漫性大B细胞淋巴瘤。发病年龄在五、六十岁。单骨型亚型通常表现为股骨或肱骨受累，而多骨型亚型常因椎体受累出现双下肢轻瘫。所有患者均接受了以环磷酰胺、阿霉素、长春新碱、泼尼松（CHOP）为基础的化疗，但仅单骨型亚型采用了根治性放疗。中位随访38个月（范围5 - 96个月），单骨型和多骨型亚型的无事件生存率分别为81%和25%。因此，多骨型PNHLB是一种预后较差的独特疾病，需要开展更大规模的研究以更好地管理该亚型。
