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基于人群队列的热性惊厥复发情况。

Recurrence of febrile convulsions in a population-based cohort.

作者信息

Annegers J F, Blakley S A, Hauser W A, Kurland L T

机构信息

Division of Epidemiology, University of Texas Health Science Center, School of Public Health, Houston 77225.

出版信息

Epilepsy Res. 1990 Apr;5(3):209-16. doi: 10.1016/0920-1211(90)90040-3.

Abstract

The risk of recurrence after an initial febrile seizure was 25% in a population-based cohort of 639 children followed from their first febrile seizure. Prognostic factors were an increasing risk of recurrence with younger age at first febrile seizure, a first degree relative with febrile seizures and complex features of the first febrile seizure. The effect of complex features was modified by age at first febrile seizure and family history in that complex features alone did not increase risk of recurrence but further increased the risk for children under 18 months at first seizure and/or with a positive family history. The prognostic factors for all febrile convulsions recurrences were also prognostic for having subsequent complex febrile convulsions. Children with none of the prognostic factors had only a 3% risk of a future complex febrile seizure while children under 18 months at first febrile convulsion and a positive family history or complex features had about a 20% risk of a subsequent complex febrile seizure.

摘要

在一项基于人群的队列研究中,对639名首次热性惊厥患儿进行随访,首次热性惊厥后复发风险为25%。预后因素包括首次热性惊厥时年龄越小复发风险越高、有热性惊厥的一级亲属以及首次热性惊厥具有复杂特征。首次热性惊厥的年龄和家族史会改变复杂特征的影响,即单纯复杂特征本身不会增加复发风险,但会进一步增加首次惊厥时年龄在18个月以下和/或有家族史阳性儿童的复发风险。所有热性惊厥复发的预后因素对于随后发生复杂性热性惊厥也具有预后意义。没有任何预后因素的儿童未来发生复杂性热性惊厥的风险仅为3%,而首次热性惊厥时年龄在18个月以下且有家族史阳性或复杂特征的儿童随后发生复杂性热性惊厥的风险约为20%。

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