门静脉狭窄所致急性门静脉高压对犬全身血流动力学的影响。

Effects of acute portal hypertension by portal venous stenosis on systemic hemodynamics in dogs.

作者信息

Moriura S, Nimura Y, Kato M, Sato T, Shionoya S

机构信息

First Department of Surgery, Nagoya University School of Medicine, Japan.

出版信息

Eur Surg Res. 1990;22(2):113-9. doi: 10.1159/000129090.

DOI:10.1159/000129090

PMID:2384124

Abstract

Effects of acute portal hypertension on systemic hemodynamics after hepatectomy were evaluated by portal venous stenosis (PVS) model in dogs. In protocol 1, portal hypertension of about twice portal venous pressure (PVP) decreased cardiac output (CO) and left atrial pressure (LAP) by 24.5% (p less than 0.01) and 1.0 mm Hg (p less than 0.01), respectively. In protocol 2, stepwise PVS demonstrated that CO change (%) and LAP change (mm Hg) were inversely proportional to PVP change (r = -0.937 and -0.883, respectively). The ratio of CO change to LAP change with stepwise PVS was comparable to that obtained by repeated hemorrhage in protocol 3. The present study shows that low CO with portal hypertension is caused by a reduction of venous return to the heart.

摘要

通过犬门静脉狭窄（PVS）模型评估急性门静脉高压对肝切除术后全身血流动力学的影响。在方案1中，门静脉高压约为门静脉压力（PVP）的两倍时，心输出量（CO）和左心房压力（LAP）分别降低了24.5%（p<0.01）和1.0 mmHg（p<0.01）。在方案2中，逐步进行门静脉狭窄显示，CO变化（%）和LAP变化（mmHg）与PVP变化成反比（r分别为-0.937和-0.883）。方案3中逐步进行门静脉狭窄时CO变化与LAP变化的比值与反复出血时获得的比值相当。本研究表明，门静脉高压时的心输出量降低是由回心血量减少所致。