Department of Pharmacy, Southwest Hospital, The Third Military Medical University, Chongqing, China.
Future Microbiol. 2013 Jul;8(7):877-86. doi: 10.2217/fmb.13.58.
Infections with bacterial or fungal biofilms have emerged as a major public heath concern because biofilm-growing cells are highly resistant to both antibiotics and host immune defenses. This review focuses on the progress in understanding the mechanisms of biofilm-specific antimicrobial resistance and in developing innovative therapeutic measures based on novel antibiofilm agents.
生物膜生长的细胞对抗生素和宿主免疫防御都具有高度抗性,因此,细菌性或真菌性生物膜感染已成为一个主要的公共卫生关注点。本综述重点介绍了在理解生物膜特异性抗微生物耐药机制方面的进展,以及基于新型抗生物膜剂开发创新治疗措施方面的进展。