PathWest Laboratory Medicine, QEII Medical Center and Sir Charles Gairdner Hospital, the University of Western Australia, Perth, Western Australia, Australia.
Pathology. 2013 Aug;45(5):484-8. doi: 10.1097/PAT.0b013e3283632649.
To study the clinical and pathological features of cases of apparent solar purpura, with attention to the recently described phenomenon of inflammatory changes within otherwise typical lesions.
We studied 95 cases diagnosed as solar purpura and identified 10 cases (10.5%) in which significant neutrophilic inflammation was present, potentially simulating a leukocytoclastic vasculitis or neutrophilic dermatosis. An additional three cases were identified in subsequent routine practice. The clinical features, including follow-up for subsequent development of vasculitis and histological features were studied.
In all cases the histological features were typical of solar purpura, with the exception of inflammatory changes, typically associated with clefting of elastotic stroma. Clinical follow-up information was available for all patients and none developed subsequent evidence of a cutaneous or systemic vasculitis or neutrophilic dermatosis.
Inflammatory changes appear to be more frequent in solar purpura than is generally recognised. Awareness of this histological variation and correlation with the clinical findings and evolution is important in avoiding misdiagnosis.
研究明显日光性紫癜病例的临床和病理特征,注意到最近描述的病变中存在炎症变化的现象。
我们研究了 95 例诊断为日光性紫癜的病例,其中 10 例(10.5%)存在明显的中性粒细胞炎症,可能模拟白细胞碎裂性血管炎或中性粒细胞皮肤病。在随后的常规实践中又发现了另外 3 例。研究了临床特征,包括随后发展为血管炎的情况和组织学特征。
除了炎症变化外,所有病例的组织学特征均为典型的日光性紫癜,炎症变化通常与弹性基质的裂隙有关。所有患者均有临床随访信息,均未出现后续皮肤或系统性血管炎或中性粒细胞皮肤病的证据。
与普遍认识相比,炎症变化似乎在日光性紫癜中更为常见。了解这种组织学变异,并与临床发现和演变相关联,对于避免误诊很重要。