Departments of Dermatology Rheumatology Ophthalmology, Sainte Elisabeth Hospital, Namur Institute of Pathology and Genetics, Gosselies Department of Dermatology, Saint Pierre Hospital, Brussels, Belgium.
Int J Dermatol. 2013 Oct;52(10):1185-8. doi: 10.1111/j.1365-4632.2011.05415.x.
The association of three neutrophilic dermatoses supports the concept of "neutrophilic disease" as a syndrome representing a continuous spectrum of clinical entities.
This report describes three neutrophilic pathologies arising in the same patient, in association with seronegative rheumatoid arthritis. The successive occurrence of erythema elevatum diutinum, pyoderma gangrenosum, and Sweet's syndrome illustrates the concept of "neutrophilic disease" developed by Wallach et al. in the 1990s. Most authors agree that neutrophilic dermatosis is defined as a cutaneous disease mainly characterized by polymorphonuclear neutrophil infiltration without infectious cause.The assessment of neutrophilic dermatosis includes identification of the type of cutaneous lesion, the existence of possible extracutaneous sites, and a search for associated disease.
The occurrence of three separate neutrophilic dermatoses in a single patient lends further support to the concept that these entities form a spectrum of diseases called neutrophilic disease.
三种嗜中性皮肤病的关联支持“嗜中性疾病”的概念，即代表临床实体连续谱的综合征。
本报告描述了同一位患者中三种嗜中性病理的发生，与血清阴性类风湿关节炎相关。先后发生的持久性隆起性红斑、坏疽性脓皮病和Sweet 综合征说明了 Wallach 等人在 20 世纪 90 年代发展的“嗜中性疾病”概念。大多数作者认为，嗜中性皮肤病定义为一种主要表现为多形核中性粒细胞浸润的皮肤疾病，没有感染原因。嗜中性皮肤病的评估包括识别皮肤病变的类型、可能存在的皮肤外部位以及寻找相关疾病。
单个患者中出现三种不同的嗜中性皮肤病进一步支持这些实体构成称为嗜中性疾病的疾病谱的概念。
