Soutou B, Vignon-Pennamen D, Chosidow O
Centre hospitalier du Nord, 100, Jdeidet, Zgharta, Liban.
Rev Med Interne. 2011 May;32(5):306-13. doi: 10.1016/j.revmed.2010.08.023. Epub 2010 Oct 8.
Neutrophilic dermatoses are inflammatory disorders where normal neutrophils infiltrate the skin without infection. Sweet's syndrome, pyoderma gangrenosum, subcorneal pustulosis, erythema elevatum diutinum and a few other conditions are included in the spectrum of neutrophilic dermatoses. In addition to their typical presentation, atypical and overlap forms of these disorders may be observed. According to the location of the neutrophilic infiltrate, three clinical forms are distinguished: superficial (epidermal), en plaques (dermal) and deep (dermal and hypodermal). During the disease course, other tissues can be affected by the same neutrophilic infiltrate. An association with other systemic diseases including malignant blood disorders, inflammatory bowel diseases and autoimmune disorders is frequent. The mechanisms leading to the invasion of the skin by neutrophils remains not completely elucidated. Treatment depends on the intensity and the acute or chronic form of the disease. In acute and severe forms, systemic corticosteroids are first-line therapy, whereas colchicine, dapsone, and even topical corticosteroids could be used in milder presentations of the disease.
嗜中性皮肤病是一种炎症性疾病，其特征为正常嗜中性粒细胞在无感染的情况下浸润皮肤。Sweet综合征、坏疽性脓皮病、角层下脓疱病、持久性隆起性红斑以及其他一些病症都属于嗜中性皮肤病范畴。除了典型表现外，还可能观察到这些病症的非典型和重叠形式。根据嗜中性粒细胞浸润的部位，可区分出三种临床类型：浅表型（表皮型）、斑块型（真皮型）和深部型（真皮及皮下型）。在疾病过程中，其他组织也可能受到相同嗜中性粒细胞浸润的影响。嗜中性皮肤病常与包括恶性血液疾病、炎症性肠病和自身免疫性疾病在内的其他全身性疾病相关。嗜中性粒细胞浸润皮肤的机制尚未完全阐明。治疗取决于疾病的严重程度以及急性或慢性形式。对于急性和严重形式的疾病，全身用皮质类固醇是一线治疗方法，而对于病情较轻的患者，可使用秋水仙碱、氨苯砜，甚至局部用皮质类固醇。
