Pentraxin 3 及其他炎症因子与视网膜中央静脉阻塞及黄斑水肿。

Pentraxin 3 and other inflammatory factors in central retinal vein occlusion and macular edema.

机构信息

*Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan; †Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan; ‡Department of Ophthalmology, Eguchi Eye Hospital, Hakodate, Japan; and §Department of Hygiene and Public Health II, Tokyo Women's Medical University, Tokyo, Japan.

出版信息

Retina. 2014 Feb;34(2):352-9. doi: 10.1097/IAE.0b013e3182993d74.

DOI:10.1097/IAE.0b013e3182993d74

PMID:23842103

Abstract

PURPOSE

To evaluate the association between vitreous fluid levels of inflammatory factors and macular edema in patients with central retinal vein occlusion (CRVO).

METHODS

In 30 CRVO patients with macular edema and 29 controls with idiopathic macular hole, vitreous fluid samples were obtained during vitreoretinal surgery. Retinal ischemia was evaluated from capillary nonperfusion on fluorescein angiography. Macular edema was examined by optical coherence tomography.

RESULTS

Vitreous fluid levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor 2 (sVEGFR-2), soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte chemotactic protein 1 (MCP-1), and pentraxin 3 (PTX3) were significantly higher in CRVO patients than in macular hole patients. Vitreous fluid levels of VEGF, sICAM-1, IL-6, MCP-1, and PTX3 were significantly correlated with the retinal thickness at the central fovea. There were significant correlations between the vitreous fluid level of VEGF and the levels of sICAM-1, IL-6, and MCP-1 in the CRVO patients. There was also a significant correlation between sVEGFR-2 and PTX3 but not between VEGF and PTX3.

CONCLUSION

These findings suggest the importance of VEGF, its signal transduction pathways, and the cytokine network and may be useful for understanding the mechanism of macular edema in CRVO and developing new treatments.

摘要

目的

评估视网膜中央静脉阻塞（CRVO）患者玻璃体炎症因子水平与黄斑水肿的关系。

方法

在 30 例伴有黄斑水肿的 CRVO 患者和 29 例特发性黄斑裂孔对照者中，通过玻璃体视网膜手术获取玻璃体样本。通过荧光素血管造影评估视网膜缺血情况。通过光学相干断层扫描检查黄斑水肿。

结果

CRVO 患者玻璃体血管内皮生长因子（VEGF）、可溶性 VEGF 受体 2（sVEGFR-2）、可溶性细胞间黏附分子 1（sICAM-1）、白细胞介素 6（IL-6）、单核细胞趋化蛋白 1（MCP-1）和五聚素 3（PTX3）水平明显高于黄斑裂孔患者。CRVO 患者玻璃体 VEGF、sICAM-1、IL-6、MCP-1 和 PTX3 水平与中央凹视网膜厚度显著相关。VEGF 与 sICAM-1、IL-6 和 MCP-1 的玻璃体水平在 CRVO 患者中呈显著相关。sVEGFR-2 与 PTX3 之间也存在显著相关性，但 VEGF 与 PTX3 之间无相关性。