高浓度C反应蛋白与低浓度五聚素3作为中心性浆液性脉络膜视网膜病变的生物标志物
High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy.
作者信息
Bousquet Elodie, Chenevier-Gobeaux Camille, Jaworski Thara, Torres-Villaros Héloïse, Zola Marta, Mantel Irmela, Kowalczuk Laura, Matet Alexandre, Daruich Alejandra, Zhao Min, Yzer Suzanne, Behar-Cohen Francine
机构信息
Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France.
Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France.
出版信息
Ophthalmol Sci. 2023 Feb 3;3(3):100278. doi: 10.1016/j.xops.2023.100278. eCollection 2023 Sep.
PURPOSE
To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.
DESIGN
Cross-sectional multicenter study.
PARTICIPANTS
Patients with CSCR compared with age- and sex-matched healthy participants.
METHODS
Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.
MAIN OUTCOME MEASURES
C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.
RESULTS
Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.
CONCLUSIONS
In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.
FINANCIAL DISCLOSURES
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
目的
鉴于五聚素3（PTX3）是一种糖皮质激素诱导蛋白，研究两种急性期蛋白C反应蛋白（CRP）和五聚素3与中心性浆液性脉络膜视网膜病变（CSCR）之间的关联。
设计
横断面多中心研究。
参与者
将CSCR患者与年龄和性别匹配的健康参与者进行比较。
方法
纳入来自欧洲3个中心的CSCR患者。记录CSCR的临床类型。采集CSCR患者和健康参与者的血样，测定血清中的高敏CRP和PTX3水平。
主要观察指标
比较CSCR患者与年龄和性别匹配的健康参与者的C反应蛋白和PTX3血清水平。
结果
尽管CSCR患者（n = 216）的CRP水平高于年龄和性别匹配的对照组（n = 130）（分别为2.2±3.2mg/l和1.5mg/l±1.4，P = 0.037），但CSCR患者的PTX3水平较低（分别为10.5±19.9pg/ml和87.4±73.2pg/ml，P<0.001）。急性/复发性和慢性CSCR患者之间的CRP或PTX3水平无显著差异。
结论
在CSCR患者中，高CRP和低PTX3水平提示一种低度全身炎症形式以及糖皮质激素途径激活不足，这为CSCR的病理生理学提出了新的假设。
财务披露
作者对本文讨论的任何材料均无所有权或商业利益。
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