Bousquet Elodie, Chenevier-Gobeaux Camille, Jaworski Thara, Torres-Villaros Héloïse, Zola Marta, Mantel Irmela, Kowalczuk Laura, Matet Alexandre, Daruich Alejandra, Zhao Min, Yzer Suzanne, Behar-Cohen Francine
Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France.
Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France.
Ophthalmol Sci. 2023 Feb 3;3(3):100278. doi: 10.1016/j.xops.2023.100278. eCollection 2023 Sep.
To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.
Cross-sectional multicenter study.
Patients with CSCR compared with age- and sex-matched healthy participants.
Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.
C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.
Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.
In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
鉴于五聚素3（PTX3）是一种糖皮质激素诱导蛋白，研究两种急性期蛋白C反应蛋白（CRP）和五聚素3与中心性浆液性脉络膜视网膜病变（CSCR）之间的关联。
横断面多中心研究。
将CSCR患者与年龄和性别匹配的健康参与者进行比较。
纳入来自欧洲3个中心的CSCR患者。记录CSCR的临床类型。采集CSCR患者和健康参与者的血样，测定血清中的高敏CRP和PTX3水平。
比较CSCR患者与年龄和性别匹配的健康参与者的C反应蛋白和PTX3血清水平。
尽管CSCR患者（n = 216）的CRP水平高于年龄和性别匹配的对照组（n = 130）（分别为2.2±3.2mg/l和1.5mg/l±1.4，P = 0.037），但CSCR患者的PTX3水平较低（分别为10.5±19.9pg/ml和87.4±73.2pg/ml，P<0.001）。急性/复发性和慢性CSCR患者之间的CRP或PTX3水平无显著差异。
在CSCR患者中，高CRP和低PTX3水平提示一种低度全身炎症形式以及糖皮质激素途径激活不足，这为CSCR的病理生理学提出了新的假设。
作者对本文讨论的任何材料均无所有权或商业利益。
