Department of Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Department of Reproductive Medicine Center, the Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Luzhou, China.
J Ovarian Res. 2022 Dec 20;15(1):132. doi: 10.1186/s13048-022-01075-0.
Ovarian reserve reflects both the quantity and quality of oocytes available for procreation and is affected by many known and unknown factors. ABO blood type is related to several infertility processes, but it is unclear whether and how ABO blood type affects ovarian reserve.
The purpose of the study was to explore the correlation between ABO blood types and ovarian reserve in infertile Chinese Han women under 40 years of age undergoing the in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI)-embryo transfer (IVF/ICSI-ET) treatment.
Women aged < 40 years who underwent IVF/ICSI-ET at our institution and had a documented ABO blood type were eligible for this study. In this study, patients were divided into two groups according to the diminished ovarian reserve (DOR) group (AMH < 1.1 ng/mL, AFC < 6) and the non-diminished ovarian reserve (non-DOR) group (AMH ≥ 1.1 ng/mL, AFC ≥ 6). The relationship between ovarian reserve and ABO blood group was determined by correlation analysis.
In this retrospective cohort study, clinical data were collected from 1690 Chinese Han women treated with IVF/ ICSI-ET in hospital records between April 2019 and March 2020 in the affiliated hospital of Southwest Medical University, located in Luzhou, China. The differences in age, duration of infertility, BMI, FSH, FSH / LH, and p (DOR vs non-DOR) for each parameter (DOR vs non-DOR) were statistically significant, and the differences in LH and E2 were not statistically significant. ABO blood groups were most prevalent in the DOR group with O (143, 34.8%) and A (122, 29.7%) and in the non-DOR group with A (428, 33.5%) and O (419, 32.8%). ABO blood groups were most prevalent in the DOR group with O (n = 57, 30.5%) and A (n = 54, 28.9%) and in the non-DOR group with A (n = 335, 34.0%) and O (n = 323, 32.8%) were the most frequent in the non-DOR group.
In this retrospective cohort study, we confirmed the lack of a significant association between ABO blood type and ovarian reserve. Further studies are needed to clarify whether there is any prognostic correlation between ABO blood group and ovarian reserve in women undergoing IVF/ICSI-ET.
卵巢储备反映了可用于生育的卵母细胞的数量和质量，受许多已知和未知因素的影响。ABO 血型与几种不孕过程有关，但尚不清楚 ABO 血型是否以及如何影响卵巢储备。
本研究旨在探讨 ABO 血型与年龄<40 岁行体外受精（IVF）/卵胞浆内单精子注射（ICSI）-胚胎移植（IVF/ICSI-ET）治疗的中国汉族不孕妇女卵巢储备之间的相关性。
本研究纳入在我院行 IVF/ICSI-ET 且 ABO 血型明确的年龄<40 岁的妇女。在本研究中，根据卵巢储备减少（DOR）组（AMH<1.1ng/ml，AFC<6）和非卵巢储备减少（非 DOR）组（AMH≥1.1ng/ml，AFC≥6），将患者分为两组。采用相关性分析确定卵巢储备与 ABO 血型之间的关系。
本回顾性队列研究共纳入 1690 例于 2019 年 4 月至 2020 年 3 月在西南医科大学附属医院行 IVF/ICSI-ET 治疗的中国汉族妇女的临床资料，该附属医院位于中国泸州。每个参数（DOR 与非 DOR）的年龄、不孕持续时间、BMI、FSH、FSH/LH 和 p（DOR 与非 DOR）的差异均有统计学意义，而 LH 和 E2 的差异无统计学意义。DOR 组 ABO 血型最常见的是 O（143，34.8%）和 A（122，29.7%），非 DOR 组 ABO 血型最常见的是 A（428，33.5%）和 O（419，32.8%）。DOR 组 ABO 血型最常见的是 O（n=57，30.5%）和 A（n=54，28.9%），非 DOR 组 ABO 血型最常见的是 A（n=335，34.0%）和 O（n=323，32.8%）。
在本回顾性队列研究中，我们证实了 ABO 血型与卵巢储备之间缺乏显著相关性。需要进一步的研究来阐明在接受 IVF/ICSI-ET 的妇女中，ABO 血型与卵巢储备之间是否存在任何预后相关性。
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