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Perit Dial Int. 2013 Jul-Aug;33(4):349-52. doi: 10.3747/pdi.2012.00320.
2
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3
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Re: Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?关于：癌抗原125作为腹膜透析生物标志物：间皮细胞健康还是死亡？
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本文引用的文献

1
Low-GDP fluid (Gambrosol trio) attenuates decline of residual renal function in PD patients: a prospective randomized study.低 GDP 液（甘丙肽三联）可减缓 PD 患者残余肾功能下降：一项前瞻性随机研究。
Nephrol Dial Transplant. 2010 Jul;25(7):2288-96. doi: 10.1093/ndt/gfq087. Epub 2010 Mar 1.
2
Benefits of biocompatible PD fluid for preservation of residual renal function in incident CAPD patients: a 1-year study.生物相容性腹膜透析液对新确诊的持续性非卧床腹膜透析患者残余肾功能的保护作用：一项为期1年的研究。
Nephrol Dial Transplant. 2009 Sep;24(9):2899-908. doi: 10.1093/ndt/gfp054. Epub 2009 Mar 3.
3
The clinical usefulness of peritoneal dialysis fluids with neutral pH and low glucose degradation product concentration: an open randomized prospective trial.具有中性pH值和低糖降解产物浓度的腹膜透析液的临床实用性：一项开放随机前瞻性试验。
Perit Dial Int. 2008 Mar-Apr;28(2):174-82.
4
Comparison between bicarbonate/lactate and standard lactate dialysis solution in peritoneal transport and ultrafiltration: a prospective, crossover single-dwell study.碳酸氢盐/乳酸盐透析液与标准乳酸盐透析液在腹膜转运和超滤方面的比较：一项前瞻性交叉单驻留研究。
Perit Dial Int. 2008 Jan-Feb;28(1):35-43.
5
Clinical biocompatibility of a neutral peritoneal dialysis solution with minimal glucose-degradation products--a 1-year randomized control trial.含最少葡萄糖降解产物的中性腹膜透析液的临床生物相容性——一项为期1年的随机对照试验
Nephrol Dial Transplant. 2007 Feb;22(2):552-9. doi: 10.1093/ndt/gfl559. Epub 2006 Sep 27.
6
Long-term clinical experience with pure bicarbonate peritoneal dialysis solutions.纯碳酸氢盐腹膜透析液的长期临床经验。
Perit Dial Int. 2006 Jan-Feb;26(1):89-94.
7
Glucose-free dialysis solutions: inductors of inflammation or preservers of peritoneal membrane?
Perit Dial Int. 2005 Sep-Oct;25(5):453-60.
8
CA125: holy grail or a poisoned chalice.
Nephron Clin Pract. 2005;100(2):c52-4. doi: 10.1159/000085033. Epub 2005 Apr 7.
9
Limitations of CA125 as an index of peritoneal mesothelial cell mass.CA125作为腹膜间皮细胞数量指标的局限性。
Nephron Clin Pract. 2005;100(2):c46-51. doi: 10.1159/000085032. Epub 2005 Apr 7.
10
Biocompatibility pattern of a bicarbonate/lactate-buffered peritoneal dialysis fluid in APD: a prospective, randomized study.碳酸氢盐/乳酸盐缓冲腹膜透析液在自动化腹膜透析中的生物相容性模式：一项前瞻性随机研究。
Nephrol Dial Transplant. 2004 Aug;19(8):2101-6. doi: 10.1093/ndt/gfh326. Epub 2004 Jun 22.

癌症抗原 125 作为腹膜透析中的生物标志物：间皮细胞的健康还是死亡？

Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?

机构信息

Division of Nephrology, University Health Network, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

出版信息

Perit Dial Int. 2013 Jul-Aug;33(4):349-52. doi: 10.3747/pdi.2012.00320.

DOI:10.3747/pdi.2012.00320
PMID:23843586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3707709/
Abstract

The concentration or appearance rate of cancer antigen 125 (CA125) in peritoneal dialysis (PD) effluent has been used for many years as a biomarker for mesothelial cell mass in patients on PD. However, this marker has limitations, and emerging evidence has raised doubts as to its significance. This review explores our current understanding of CA125, its prominent role in studies of "biocompatible" PD solutions, and the ongoing uncertainty concerning its interpretation as a measure of mesothelial cell health.

摘要

腹腔透析（PD）流出液中癌抗原 125（CA125）的浓度或出现率多年来一直被用作 PD 患者间皮细胞质量的生物标志物。然而，这种标志物存在局限性，新出现的证据对其意义提出了质疑。本文探讨了我们目前对 CA125 的认识，它在“生物相容”PD 溶液研究中的突出作用，以及作为间皮细胞健康衡量标准的解释存在的持续不确定性。