癌症抗原 125 作为腹膜透析中的生物标志物：间皮细胞的健康还是死亡？
Cancer antigen 125 as a biomarker in peritoneal dialysis: mesothelial cell health or death?
机构信息
Division of Nephrology, University Health Network, and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
出版信息
Perit Dial Int. 2013 Jul-Aug;33(4):349-52. doi: 10.3747/pdi.2012.00320.
The concentration or appearance rate of cancer antigen 125 (CA125) in peritoneal dialysis (PD) effluent has been used for many years as a biomarker for mesothelial cell mass in patients on PD. However, this marker has limitations, and emerging evidence has raised doubts as to its significance. This review explores our current understanding of CA125, its prominent role in studies of "biocompatible" PD solutions, and the ongoing uncertainty concerning its interpretation as a measure of mesothelial cell health.
腹腔透析（PD）流出液中癌抗原 125（CA125）的浓度或出现率多年来一直被用作 PD 患者间皮细胞质量的生物标志物。然而，这种标志物存在局限性，新出现的证据对其意义提出了质疑。本文探讨了我们目前对 CA125 的认识，它在“生物相容”PD 溶液研究中的突出作用，以及作为间皮细胞健康衡量标准的解释存在的持续不确定性。
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