Gauthier Thomas D
ENVIRON International Corp., Tampa, Florida.
Anal Chem Insights. 2013 Jun 6;8:29-40. doi: 10.4137/ACI.S11993. Print 2013.
1,3-Dimethylamylamine (1,3-DMAA) is an aliphatic amine with stimulant properties that are reportedly found naturally only in geranium plants (Pelargonium graveolens). The presence of 1,3-DMAA in geranium plants was first reported in a paper published in 1996, but some have questioned the identification of 1,3-DMAA in that study. Since then, a number of additional studies have been published, largely reporting the absence of 1,3-DMAA in geranium plants and commercial geranium oils. However, in two recent studies, 1,3-DMAA was detected in geranium plant tissues and a geranium oil sample using a simplified extraction approach on tissues and oil sourced from China. Whether or not 1,3-DMAA is found naturally in plants has significant implications as to how commercial products containing 1,3-DMAA are regulated by the US Food and Drug Administration. In this paper, differences in source materials, extraction procedures, and analytical approaches are reviewed in an attempt to rationalize the apparently conflicting evidence for the presence of 1,3-DMAA in geranium plant materials.
1,3 - 二甲基戊胺（1,3 - DMAA）是一种具有刺激特性的脂肪族胺，据报道仅天然存在于天竺葵植物（香叶天竺葵）中。天竺葵植物中1,3 - DMAA的存在最早在1996年发表的一篇论文中被报道，但一些人对该研究中1,3 - DMAA的鉴定提出了质疑。从那时起，又发表了一些其他研究，大多报告在天竺葵植物和商业天竺葵油中不存在1,3 - DMAA。然而，在最近的两项研究中，使用一种简化的提取方法，在来自中国的植物组织和油样中检测到了天竺葵植物组织和一个天竺葵油样品中的1,3 - DMAA。1,3 - DMAA是否天然存在于植物中，对于美国食品药品监督管理局如何监管含有1,3 - DMAA的商业产品具有重大影响。在本文中，对原材料、提取程序和分析方法的差异进行了综述，试图使关于天竺葵植物材料中存在1,3 - DMAA的明显相互矛盾的证据合理化。
