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重组水痘-带状疱疹病毒疫苗作为表达外源抗原的平台。

Recombinant varicella-zoster virus vaccines as platforms for expression of foreign antigens.

作者信息

Gray Wayne L

机构信息

Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA.

出版信息

Adv Virol. 2013;2013:219439. doi: 10.1155/2013/219439. Epub 2013 Jun 13.

DOI:10.1155/2013/219439
PMID:23843791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3697282/
Abstract

Varicella-zoster virus (VZV) vaccines induce immunity against childhood chickenpox and against shingles in older adults. The safety, efficacy, and widespread use of VZV vaccines suggest that they may also be effective as recombinant vaccines against other infectious diseases that affect the young and the elderly. The generation of recombinant VZV vaccines and their evaluation in animal models are reviewed. The potential advantages and limitations of recombinant VZV vaccines are addressed.

摘要

水痘带状疱疹病毒（VZV）疫苗可诱导针对儿童水痘以及老年人群带状疱疹的免疫力。VZV疫苗的安全性、有效性及广泛应用表明，它们作为重组疫苗可能对其他影响年轻人和老年人的传染病也有效。本文综述了重组VZV疫苗的研发及其在动物模型中的评估，并探讨了重组VZV疫苗的潜在优势和局限性。

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Recombinant varicella-zoster virus vaccines as platforms for expression of foreign antigens.重组水痘-带状疱疹病毒疫苗作为表达外源抗原的平台。
Adv Virol. 2013;2013:219439. doi: 10.1155/2013/219439. Epub 2013 Jun 13.
2
Abortive intrabronchial infection of rhesus macaques with varicella-zoster virus provides partial protection against simian varicella virus challenge.恒河猴经水痘-带状疱疹病毒进行支气管内感染减毒后，可对猴水痘病毒攻击提供部分保护。
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3
CD4 T cell immunity is critical for the control of simian varicella virus infection in a nonhuman primate model of VZV infection.CD4 T 细胞免疫对于控制猴痘病毒感染的非人类灵长类动物模型中的猴痘病毒感染至关重要。
PLoS Pathog. 2011 Nov;7(11):e1002367. doi: 10.1371/journal.ppat.1002367. Epub 2011 Nov 10.
4
Prevention of shingles: safety and efficacy of live zoster vaccine.带状疱疹的预防：带状疱疹活疫苗的安全性和有效性。
Ther Clin Risk Manag. 2007 Aug;3(4):633-9.
5
Advances in the treatment of varicella-zoster virus infections.水痘-带状疱疹病毒感染的治疗进展
Adv Pharmacol. 2013;67:107-68. doi: 10.1016/B978-0-12-405880-4.00004-4.
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Evaluation of glycoprotein E subunit and live attenuated varicella-zoster virus vaccines formulated with a single-strand RNA-based adjuvant.评价基于单链 RNA 佐剂的糖蛋白 E 亚单位和减毒活水痘带状疱疹病毒疫苗。
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Varicella-zoster virus infection: natural history, clinical manifestations, immunity and current and future vaccination strategies.水痘-带状疱疹病毒感染：自然史、临床表现、免疫以及当前和未来的疫苗接种策略。
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Animal models of varicella zoster virus infection.水痘带状疱疹病毒感染的动物模型。
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Vaccines for preventing herpes zoster in older adults.预防老年人带状疱疹的疫苗。
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Insertion of foreign genes into the simian varicella virus genome by Tn7-mediated site-specific transposition.通过 Tn7 介导的位点特异性转座将外源基因插入猴痘病毒基因组。
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本文引用的文献

1
Latency of varicella zoster virus in dorsal root, cranial, and enteric ganglia in vaccinated children.接种疫苗儿童中水痘带状疱疹病毒在背根神经节、颅神经节和肠神经节中的潜伏情况。
Trans Am Clin Climatol Assoc. 2012;123:17-33; discussion 33-5.
2
Increased cellular immune responses and CD4+ T-cell proliferation correlate with reduced plasma viral load in SIV challenged recombinant simian varicella virus - simian immunodeficiency virus (rSVV-SIV) vaccinated rhesus macaques.在 SIV challenged 重组猴痘病毒-猴免疫缺陷病毒（rSVV-SIV）疫苗接种的恒河猴中，细胞免疫反应和 CD4+T 细胞增殖增加与血浆病毒载量降低相关。
Virol J. 2012 Aug 13;9:160. doi: 10.1186/1743-422X-9-160.
3
Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation.
水痘带状疱疹病毒活疫苗不会诱导 HIV 靶细胞激活。
J Clin Invest. 2019 Feb 1;129(2):875-886. doi: 10.1172/JCI124473. Epub 2019 Jan 22.
4
Live Attenuated Zoster Vaccine Boosts Varicella Zoster Virus (VZV)-Specific Humoral Responses Systemically and at the Cervicovaginal Mucosa of Kenyan VZV-Seropositive Women.减毒带状疱疹疫苗可增强肯尼亚 VZV 血清阳性女性全身和宫颈阴道黏膜的水痘带状疱疹病毒（VZV）特异性体液免疫应答。
J Infect Dis. 2018 Sep 8;218(8):1210-1218. doi: 10.1093/infdis/jiy320.
5
Protocol of a randomised controlled trial characterising the immune responses induced by varicella-zoster virus (VZV) vaccination in healthy Kenyan women: setting the stage for a potential VZV-based HIV vaccine.一项随机对照试验的方案，该试验旨在表征肯尼亚健康女性接种水痘带状疱疹病毒（VZV）疫苗所诱导的免疫反应：为潜在的基于VZV的HIV疫苗奠定基础。
BMJ Open. 2017 Sep 21;7(9):e017391. doi: 10.1136/bmjopen-2017-017391.
6
Multivalent and Multipathogen Viral Vector Vaccines.多价和多病原体病毒载体疫苗
Clin Vaccine Immunol. 2017 Jan 5;24(1). doi: 10.1128/CVI.00298-16. Print 2017 Jan.
Management of varicella infection (chickenpox) in pregnancy.
妊娠期水痘感染（水痘）的管理。
J Obstet Gynaecol Can. 2012 Mar;34(3):287-292. doi: 10.1016/S1701-2163(16)35190-8.
4
Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years.带状疱疹疫苗在 50-59 岁人群中的疗效、安全性和耐受性。
Clin Infect Dis. 2012 Apr;54(7):922-8. doi: 10.1093/cid/cir970. Epub 2012 Jan 30.
5
Experience with use of Zostavax(®) in patients with hematologic malignancy and hematopoietic cell transplant recipients.在血液系统恶性肿瘤患者和造血干细胞移植受者中使用重组带状疱疹疫苗（Zostavax(®)）的经验。
Am J Hematol. 2012 Jan;87(1):123-5. doi: 10.1002/ajh.22196. Epub 2011 Nov 4.
6
Viral vectors as vaccine platforms: deployment in sight.病毒载体作为疫苗平台：部署在望。
Curr Opin Immunol. 2011 Jun;23(3):377-82. doi: 10.1016/j.coi.2011.03.006. Epub 2011 Apr 20.
7
Cloning the simian varicella virus genome in E. coli as an infectious bacterial artificial chromosome.将猴痘病毒基因组在大肠杆菌中克隆为感染性细菌人工染色体。
Arch Virol. 2011 May;156(5):739-46. doi: 10.1007/s00705-010-0889-4. Epub 2011 Apr 13.
8
Review: The neurobiology of varicella zoster virus infection.综述：水痘-带状疱疹病毒感染的神经生物学。
Neuropathol Appl Neurobiol. 2011 Aug;37(5):441-63. doi: 10.1111/j.1365-2990.2011.01167.x.
9
Recombinant varicella vaccines induce neutralizing antibodies and cellular immune responses to SIV and reduce viral loads in immunized rhesus macaques.重组水痘疫苗可诱导 SIV 的中和抗体和细胞免疫应答，并降低免疫恒河猴的病毒载量。
Vaccine. 2010 Sep 7;28(39):6483-90. doi: 10.1016/j.vaccine.2010.07.018. Epub 2010 Jul 21.
10
Zoster vaccine: current status and future prospects.带状疱疹疫苗：现状与未来前景。
Clin Infect Dis. 2010 Jul 15;51(2):197-213. doi: 10.1086/653605.