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老年患者中表现为持续发热的缓慢进展性无痛性胸主动脉夹层:生化参数联合检测的作用

Slowly progressive and painless thoracic aortic dissection presenting with a persistent Fever in an elderly patient: the usefulness of combined measurement of biochemical parameters.

作者信息

Yamada Shunsuke, Tokumoto Masanori, Ohkuma Toshiaki, Kansui Yasuo, Wakisaka Yoshinobu, Uchizono Yuji, Tsuruya Kazuhiko, Kitazono Takanari, Ooboshi Hiroaki

机构信息

Division of Internal Medicine, Fukuoka Dental College, 2-15-1 Tamura, Sawara-Ku, Fukuoka 814-0193, Japan ; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

出版信息

Case Rep Med. 2013;2013:498129. doi: 10.1155/2013/498129. Epub 2013 Jun 17.

DOI:10.1155/2013/498129
PMID:23843799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3703400/
Abstract

Aortic dissection is a fatal medical condition that requires urgent diagnosis and appropriate intervention. Because acute aortic dissection often manifests as sudden onset excruciating chest pain, physicians can easily reach a proper diagnosis. However, some patients with aortic dissection present with varied clinical manifestations without exhibiting typical chest pain, leading to a delayed diagnosis and possible fatality. We herein present the case of an elderly subject with a fever of unknown origin who was ultimately diagnosed with aortic dissection. In the present case, a negative procalcitonin test, increased D-dimer and serum creatinine phosphokinase-BB levels, and reelevation of the CPR level led us to the correct diagnosis.

摘要

主动脉夹层是一种致命的疾病,需要紧急诊断和适当干预。由于急性主动脉夹层常表现为突发的剧烈胸痛,医生很容易做出正确诊断。然而,一些主动脉夹层患者临床表现各异,无典型胸痛症状,导致诊断延迟并可能致死。我们在此报告一例不明原因发热的老年患者,最终被诊断为主动脉夹层。在本病例中,降钙素原检测阴性、D-二聚体及血清肌酸磷酸激酶-BB水平升高,以及CPR水平再次升高,使我们做出了正确诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cac/3703400/a7b18c5af0a1/CRIM.MEDICINE2013-498129.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cac/3703400/585e683393e3/CRIM.MEDICINE2013-498129.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cac/3703400/a7b18c5af0a1/CRIM.MEDICINE2013-498129.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cac/3703400/585e683393e3/CRIM.MEDICINE2013-498129.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cac/3703400/a7b18c5af0a1/CRIM.MEDICINE2013-498129.002.jpg

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本文引用的文献

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Lancet Infect Dis. 2013 May;13(5):426-35. doi: 10.1016/S1473-3099(12)70323-7. Epub 2013 Feb 1.
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Utility of measuring C-reactive protein for prediction of in-hospital events in patients with acute aortic dissection.检测C反应蛋白对预测急性主动脉夹层患者院内事件的效用
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Aortic dissection: prompt diagnosis and emergency treatment are critical.
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主动脉夹层:及时诊断和紧急治疗至关重要。
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BMC Med. 2011 Sep 22;9:107. doi: 10.1186/1741-7015-9-107.
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Peak C-reactive protein level predicts long-term outcomes in type B acute aortic dissection.C 反应蛋白峰值水平可预测 B 型急性主动脉夹层的远期预后。
Hypertension. 2010 Feb;55(2):422-9. doi: 10.1161/HYPERTENSIONAHA.109.143131. Epub 2009 Dec 28.
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Diagnosis of acute aortic dissection by D-dimer: the International Registry of Acute Aortic Dissection Substudy on Biomarkers (IRAD-Bio) experience.D-二聚体用于急性主动脉夹层的诊断:急性主动脉夹层生物标志物国际注册研究(IRAD-Bio)的经验
Circulation. 2009 May 26;119(20):2702-7. doi: 10.1161/CIRCULATIONAHA.108.833004. Epub 2009 May 11.
7
Inflammatory response is associated with aortic dissection.炎症反应与主动脉夹层相关。
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9
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Acta Cardiol. 2007 Aug;62(4):409-11. doi: 10.2143/AC.62.4.2022286.
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