Maclean J M, Phippard A F, Thompson J F, Gillin A G, Horvath J S, Duggin G G, Tiller D J
Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
J Appl Physiol (1985). 1990 Jun;68(6):2373-9. doi: 10.1152/jappl.1990.68.6.2373.
A method is described for comprehensive hemodynamic study of undisturbed baboons (Papio hamadryas) that incorporates cardiac output measurement by thermodilution. Instrumentation includes arterial, aortic, and central venous catheterization by a surgical technique that does not require entry to peritoneal or thoracic cavities. It provides a means for right atrial indicator delivery with aortic temperature recording of thermodilution curves. Accuracy was confirmed by comparison to measurement by Swan-Ganz catheters. Diurnal variations of systemic arterial pressure in long-term study of conscious baboons were shown to result from significant increases in cardiac output by day (P less than 0.001), despite concomitant falls in systemic vascular resistance. The cardiac output values obtained were 0.13 l.min-1.kg-1 at night and 0.16 l.min-1.kg-1 by day. Comparison of these results to previous reports of cardiac output in baboons highlights the inadequacies of methods that require physical restraint or anesthesia. This technique also leaves the baboons intact for subsequent breeding or experimental use after catheter removal without the need for further surgery.
本文描述了一种对未受干扰的狒狒（阿拉伯狒狒）进行全面血流动力学研究的方法，该方法采用热稀释法测量心输出量。仪器设备包括通过一种无需进入腹腔或胸腔的外科技术进行动脉、主动脉和中心静脉插管。它提供了一种通过右心房指示剂给药并记录主动脉热稀释曲线温度的方法。通过与Swan-Ganz导管测量结果进行比较，证实了该方法的准确性。在对清醒狒狒的长期研究中发现，尽管体循环血管阻力同时下降，但白天的心输出量显著增加（P小于0.001），导致体循环动脉压出现昼夜变化。夜间获得的心输出量值为0.13升·分钟-1·千克-1，白天为0.16升·分钟-1·千克-1。将这些结果与之前关于狒狒心输出量的报告进行比较，凸显了需要身体约束或麻醉的方法的不足之处。该技术还使狒狒在拔除导管后保持完整，可用于后续繁殖或实验，无需进一步手术。
