Klayton R, Fallat R, Cohen A B
Am Rev Respir Dis. 1975 Jul;112(1):71-5. doi: 10.1164/arrd.1975.112.1.71.
We examined elderly heterozygotes for alpha-antitrypsin deficiency (phenotype MZ) to determine which of several factors might be associated with the development of chronic obstructive pulmonary disease (COPD). Elderly heterozygotes who smoked had a very high incidence of COPD (70 per cent), whereas homozygotes (phenotype MM) who smoked had a significantly lower incidence of COPD (35 per cent). There was no difference in the incidence of COPD between subjects with MM and MZ phenotypes who did not smoke. To determine if leukocyte enzymes were related to the development of COPD in elderly heterozygotes, we measured the activities of monocytic acid cathepsin, neutrophil acid cathepsin, neutral cathepsin, and elastase. The activities of these enzymes were not associated with the development of COPD or with smoking history in the heterozygotes. In conclusion, cigarette smoking seemed to be a significant determinant of the development of COPD in heterozygotes for alpha-antitrypsin deficiency, but the leukocyte enzyme actitivty that we studied was unrelated.
我们对老年α-抗胰蛋白酶缺乏杂合子（MZ表型）进行了研究，以确定几种因素中哪些可能与慢性阻塞性肺疾病（COPD）的发生有关。吸烟的老年杂合子患COPD的发生率非常高（70%），而吸烟的纯合子（MM表型）患COPD的发生率则显著较低（35%）。不吸烟的MM和MZ表型受试者之间COPD的发生率没有差异。为了确定白细胞酶是否与老年杂合子中COPD的发生有关，我们测量了单核细胞酸性组织蛋白酶、中性粒细胞酸性组织蛋白酶、中性组织蛋白酶和弹性蛋白酶的活性。这些酶的活性与杂合子中COPD的发生或吸烟史无关。总之，吸烟似乎是α-抗胰蛋白酶缺乏杂合子中COPD发生的一个重要决定因素，但我们研究的白细胞酶活性与之无关。
