Henry T R, Mazziotta J C, Engel J, Christenson P D, Zhang J X, Phelps M E, Kuhl D E
Department of Neurology, School of Medicine, University of California, Los Angeles.
J Cereb Blood Flow Metab. 1990 Sep;10(5):748-57. doi: 10.1038/jcbfm.1990.128.
The majority of patients with complex partial seizures of unilateral temporal lobe origin have interictal temporal hypometabolism on [18F]fluorodeoxyglucose positron emission tomography (FDG PET) studies. Often, this hypometabolism extends to ipsilateral extratemporal sites. The use of accurately quantified metabolic data has been limited by the absence of an equally reliable method of anatomical analysis of PET images. We developed a standardized method for visual placement of anatomically configured regions of interest on FDG PET studies, which is particularly adapted to the widespread, asymmetric, and often severe interictal metabolic alterations of temporal lobe epilepsy. This method was applied by a single investigator, who was blind to the identity of subjects, to 10 normal control and 25 interictal temporal lobe epilepsy studies. All subjects had normal brain anatomical volumes on structural neuroimaging studies. The results demonstrate ipsilateral thalamic and temporal lobe involvement in the interictal hypometabolism of unilateral temporal lobe epilepsy. Ipsilateral frontal, parietal, and basal ganglial metabolism is also reduced, although not as markedly as is temporal and thalamic metabolism.
大多数起源于单侧颞叶的复杂部分性癫痫患者在[18F]氟脱氧葡萄糖正电子发射断层扫描（FDG PET）研究中表现为发作间期颞叶代谢减低。通常，这种代谢减低会扩展到同侧颞叶外区域。由于缺乏同样可靠的PET图像解剖分析方法，准确量化代谢数据的应用受到了限制。我们开发了一种标准化方法，用于在FDG PET研究中可视化放置解剖结构配置的感兴趣区域，该方法特别适用于颞叶癫痫广泛、不对称且通常严重的发作间期代谢改变。一名对受试者身份不知情的研究人员将该方法应用于10例正常对照和25例发作间期颞叶癫痫研究。所有受试者在结构神经影像学研究中脑解剖体积均正常。结果表明，同侧丘脑和颞叶参与了单侧颞叶癫痫的发作间期代谢减低。同侧额叶、顶叶和基底神经节的代谢也有所降低，尽管不如颞叶和丘脑代谢明显。
