Ielpo Benedetto, Ferri Valentina, Caruso Riccardo, Duran Hipolito, Diaz Eduardo, Fabra Isabel, Oliva Catalina, Olivares Sergio, Quijano Yolanda, Vicente Emilio
General Surgery Department, Madrid Sanchinarro University Hospital, San Pablo University. Madrid, Spain.
JOP. 2013 Jul 10;14(4):432-7. doi: 10.6092/1590-8577/1468.
The clinical benefits of distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer remains controversial and, therefore, declared unresectable in most cases. Appleby first described extended distal pancreatectomy with celiac axis resection for locally advanced gastric cancer.
We report a case of a 65-year-old female who presented a locally advanced pancreatic carcinoma with infiltration of celiac axis. After radio-chemo neoadjuvant treatment, the patient underwent exploratory laparoscopy and subsequent distal pancreatectomy with en bloc resection of celiac axis. Arterial reconstruction was necessary as hepatic flow was not adequate, determined by intraoperative Doppler ultrasonography. It consisted of end to end anastomosis with prosthetic graft between hepatic artery directly to the aorta, as an atheromatous plaque was at the origin of the celiac axis. The postoperative course was uneventful with a perfect relief of pain. She presents a long term survival of 36 months, very exceptional for this type of disease.
The particularity of this case is not only the surgical treatment, rarely offered to these patients, but also and especially the subsequent vascular reconstruction. To our knowledge, this is the first report of this type of arterial reconstruction. Besides, we briefly discuss the recent advances in results of extended distal pancreatectomy with arterial resection for locally advanced pancreatic carcinoma.
对于局部进展期胰体癌行胰远端切除术并整块切除腹腔干,其临床益处仍存在争议,因此在大多数情况下被判定为不可切除。阿普尔比首次描述了针对局部进展期胃癌行扩大胰远端切除术并切除腹腔干。
我们报告一例65岁女性,患有局部进展期胰腺癌并侵犯腹腔干。经过放化疗新辅助治疗后,患者接受了 exploratory laparoscopy(此处英文有误,推测可能是“exploratory laparotomy”,即剖腹探查术),随后行胰远端切除术并整块切除腹腔干。由于术中多普勒超声检查确定肝血流不足,因此需要进行动脉重建。重建方式为在肝动脉直接与主动脉之间用人工血管进行端端吻合,因为腹腔干起始处有动脉粥样硬化斑块。术后过程顺利,疼痛完全缓解。她已存活36个月,对于这种类型的疾病来说非常罕见。
该病例的特殊性不仅在于这种很少为这类患者实施的手术治疗,还尤其在于随后的血管重建。据我们所知,这是此类动脉重建的首例报告。此外,我们简要讨论了针对局部进展期胰腺癌行扩大胰远端切除术并切除动脉的近期研究进展。