"Dan Setlacec" Center of Gastrointestinal Diseases and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
"Titu Maiorescu" University of Medicine and Pharmacy, Bucharest, Romania.
In Vivo. 2020 May-Jun;34(3):1521-1525. doi: 10.21873/invivo.11940.
BACKGROUND/AIM: Locally advanced pancreatic body tumors invading the celiac axis and the portal vein have been considered since long as unresectable lesions; however, due to improvement of surgical techniques, in certain cases surgery with curative intent might be taken in consideration.
We present the case of a 48-year-old female investigated for epigastric pain that was diagnosed with a locally invasive pancreatic body tumor. The patient was submitted to computed tomography which revealed the presence of a locally advanced pancreatic tumor with no demarcation line with the celiac axis and the portal vein. The endoscopic ultrasound raised the suspicion of malignancy and retrieved a biopsy which demonstrated the presence of a pancreatic adenocarcinoma. The patient was submitted to surgery, distal pancreatectomy en bloc with splenectomy, celiac axis and portal vein resection was performed; the hepatic artery was reconstructed by placing a cadaveric graft while the portal vein was sutured per primam by an end to end anastomosis. The postoperative outcome was favorable, and the patient was discharged in the 10 postoperative day.
Multiple vascular resections followed by reconstructions might be needed in order to achieve resection with negative margins in patients with pancreatic body tumors.
背景/目的:长期以来,侵犯腹腔干和门静脉的胰体部局部进展期肿瘤被认为是不可切除的病变;然而,由于手术技术的提高,在某些情况下,可能会考虑进行根治性手术。
我们报告了一例 48 岁女性上腹痛的病例,经检查诊断为胰体部局部侵袭性肿瘤。患者行计算机断层扫描显示存在局部晚期胰体肿瘤,与腹腔干和门静脉无分界线。内镜超声怀疑为恶性肿瘤,并进行了活检,结果显示为胰腺腺癌。患者接受了手术治疗,行胰体尾部连同脾脏整块切除术、腹腔干和门静脉切除术;肝动脉通过放置尸体移植物进行重建,而门静脉通过端端吻合进行缝合修复。术后结果良好,患者在术后第 10 天出院。
为了实现胰体部肿瘤的阴性切缘切除,可能需要进行多次血管切除和重建。