* Marmara University, School of Medicine, Department of Obstetrics and Gynecology , Istanbul.
Climacteric. 2014 Jun;17(3):268-72. doi: 10.3109/13697137.2013.823393. Epub 2013 Aug 28.
To determine the association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values in postmenopausal women. Methods One hundred healthy postmenopausal women were included in a cross-sectional study. Venous blood was collected after an overnight fast and 25-hydroxyvitamin D, glucose and insulin levels were measured. HOMA-IR was calculated. Bone mineral density was measured with a dual X-ray absorptiometer.
There was no difference in serum 25-hydroxyvitamin D levels and HOMA-IR values between the two groups. A weak positive correlation between serum 25-hydroxyvitamin D levels and osteopenia was detected. Insulin resistance had a weak negative association with osteopenia.
The correlations between osteopenia and serum 25-hydroxyvitamin D levels and HOMA-IR values were weak among early postmenopausal women.
探讨绝经后妇女骨质疏松症与血清 25-羟维生素 D 水平及 HOMA-IR 值的关系。方法：采用横断面研究，选取 100 例健康绝经后妇女，禁食过夜后采集静脉血，检测血清 25-羟维生素 D、血糖和胰岛素水平，计算 HOMA-IR。采用双能 X 线吸收仪测量骨密度。结果：两组间血清 25-羟维生素 D 水平和 HOMA-IR 值无差异。血清 25-羟维生素 D 水平与骨质疏松症呈弱正相关，胰岛素抵抗与骨质疏松症呈弱负相关。结论：在绝经早期妇女中，骨质疏松症与血清 25-羟维生素 D 水平及 HOMA-IR 值的相关性较弱。
