绝经后女性血清25-羟基维生素D水平与身体成分之间的关联：绝经后健康研究
Association between serum 25-hydroxyvitamin D levels and body composition in postmenopausal women: the postmenopausal Health Study.
作者信息
Moschonis George, Tanagra Sofia, Koutsikas Konstantinos, Nikolaidou Anna, Androutsos Odysseas, Manios Yannis
机构信息
Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece.
出版信息
Menopause. 2009 Jul-Aug;16(4):701-7. doi: 10.1097/gme.0b013e318199d5d5.
OBJECTIVE
The present study examined the association between body composition measurements, using dual-energy x-ray absorptiometry and anthropometry, with serum 25-hydroxyvitamin D levels in nonosteoporotic, postmenopausal women.
METHODS
Serum 25-hydroxyvitamin D, intact parathyroid hormone, insulin-like growth factor I levels, dual-energy x-ray absorptiometry measurements of fat and fat-free mass, anthropometric and handgrip strength measurements, dietary intake estimations, ultraviolet B radiation exposure, and physical activity levels were collected from 112 nonosteoporotic, postmenopausal women (age, 60.3 +/- 5.0 y; body mass index, 29.5 +/- 4.8 kg/m).
RESULTS
At a bivariate level, serum 25-hydroxyvitamin D levels were inversely associated with regional and total body fat mass (P < 0.05), whereas positive associations were observed with regional and total body fat-free mass (P < 0.05). After controlling for age, serum intact parathyroid hormone, insulin-like growth factor I levels, ultraviolet B radiation exposure, and physical activity levels, most of the associations observed at a bivariate level between serum 25-hydroxyvitamin D levels and body composition indices (as obtained by dual-energy x-ray absorptiometry) remained significant. No significant associations were observed between anthropometric indices of body mass and serum 25-hydroxyvitamin D levels.
CONCLUSIONS
An independent inverse association between serum 25-hydroxyvitamin D levels and dual-energy x-ray absorptiometry measurements of total body and regional fat mass was observed in nonosteoporotic, overweight, postmenopausal women. Further clinical trials are required to come to safe conclusions on whether it is the fat mass that affects serum 25-hydroxyvitamin D levels or vice versa and whether there is a need to also take into account body composition when providing recommendations for vitamin D intake in postmenopausal women.
目的
本研究探讨了采用双能X线吸收法和人体测量法测得的身体成分测量值与非骨质疏松绝经后女性血清25-羟维生素D水平之间的关联。
方法
收集了112名非骨质疏松绝经后女性（年龄60.3±5.0岁；体重指数29.5±4.8kg/m²）的血清25-羟维生素D、完整甲状旁腺激素、胰岛素样生长因子I水平、双能X线吸收法测量的脂肪和去脂体重、人体测量和握力测量、饮食摄入量估计、紫外线B辐射暴露及身体活动水平。
结果
在双变量水平上，血清25-羟维生素D水平与局部及全身脂肪量呈负相关（P<0.05），而与局部及全身去脂体重呈正相关（P<0.05）。在控制年龄、血清完整甲状旁腺激素、胰岛素样生长因子I水平、紫外线B辐射暴露及身体活动水平后，双变量水平上观察到的血清25-羟维生素D水平与身体成分指数（通过双能X线吸收法获得）之间的大多数关联仍具有显著性。体重的人体测量指标与血清25-羟维生素D水平之间未观察到显著关联。
结论
在非骨质疏松、超重的绝经后女性中，观察到血清25-羟维生素D水平与双能X线吸收法测量的全身及局部脂肪量之间存在独立的负相关。需要进一步的临床试验才能得出关于是脂肪量影响血清25-羟维生素D水平还是反之，以及在为绝经后女性提供维生素D摄入建议时是否也需要考虑身体成分的安全结论。
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