Obstetrics and Gynaecology, School of Medicine, University of Glasgow, UK.
Climacteric. 2013 Aug;16 Suppl 1:31-6. doi: 10.3109/13697137.2013.805525. Epub 2013 Jun 12.
Vasomotor symptoms are the most common indication for the prescription of hormone replacement therapy since it is effective in over 80% of cases. In 1995, 37% of American women took hormone replacement therapy, principally for this purpose. However, following the publication of results from the Women's Health Initiative, as many as half of these women in the US and in the UK and New Zealand discontinued hormone therapy. Discontinuation of estrogen is often accompanied by a return of vasomotor symptoms; however, only a small number (18%) of women report restarting hormone therapy. Alternatives are available, but limited knowledge on etiology and mechanisms of hot flushing represents a major obstacle for the development of new, targeted, non-hormonal treatments, and no current alternatives are as effective as estrogen.
血管舒缩症状是激素替代疗法处方的最常见指征，因为它在超过 80%的病例中有效。1995 年，37%的美国女性服用激素替代疗法，主要就是出于这个目的。然而，在妇女健康倡议的研究结果公布后，美国、英国和新西兰多达一半的女性停止了激素治疗。停止使用雌激素往往伴随着血管舒缩症状的再次出现；然而，只有少数（18%）女性报告重新开始激素治疗。有替代方法，但对热潮红的病因和机制的了解有限，这是开发新的、有针对性的、非激素治疗方法的主要障碍，目前没有任何替代方法像雌激素那样有效。
