Honda Y, Nakano M, Haratake M, Sugii A
Department of Pharmacy, Kumamoto University Hospital, Japan.
J Pharmacobiodyn. 1990 Feb;13(2):130-5. doi: 10.1248/bpb1978.13.130.
The effect of a new polystyrene-based, strongly basic, anion-exchange resin possessing an omega-oxobutyl chain as a spacer arm on the fecal bile acid excretion was investigated in rats and compared with that of Dowex 1-X2, chemically equivalent to cholestyramine. The new resin did produce a significant rise in the total fecal bile acid excretion with its ingestion for a period of 4 weeks. Its promoting activity proved to be 2.0- and 1.8-fold more potent than that of Dowex 1-X2 at the 3rd and 4th week, respectively. These results suggest that the introduction of a spacer arm between the polymer backbone and a functional group would lead to an improvement in the in vivo adsorptive efficiency of the resin.
研究了一种新型的以聚苯乙烯为基础、具有强碱性、带有ω-氧代丁基链作为间隔臂的阴离子交换树脂对大鼠粪便胆汁酸排泄的影响，并与化学性质等同于消胆胺的Dowex 1-X2进行了比较。摄入这种新型树脂4周后，确实使粪便中胆汁酸的总排泄量显著增加。在第3周和第4周时，其促进活性分别比Dowex 1-X2高2.0倍和1.8倍。这些结果表明，在聚合物主链和官能团之间引入间隔臂会提高树脂在体内的吸附效率。
