Toda H, Kihara K, Hashimoto M, Mizogami S
Central Research Laboratory, Mitsubishi Yuka Company, Ltd., Ibaraki, Japan.
J Pharm Sci. 1988 Jun;77(6):531-3. doi: 10.1002/jps.2600770614.
A new anion exchange resin with an imidazolium salt on a epoxide polymer skeleton was synthesized. This white powder material was odorless and tasteless. The in vitro sodium cholate binding of this resin was much more potent than that of cholestyramine. The hypocholesterolemic activity of this resin in cholesterol-fed rabbits proved to be 4.3 times more potent than that of cholestyramine. These results suggest that effective reduction of plasma cholesterol may be achieved with lower doses of this resin.
合成了一种在环氧聚合物骨架上带有咪唑盐的新型阴离子交换树脂。这种白色粉末状物质无味无臭。该树脂在体外对胆酸钠的结合能力比消胆胺强得多。在喂食胆固醇的兔子中，这种树脂的降胆固醇活性被证明比消胆胺强4.3倍。这些结果表明，使用较低剂量的这种树脂可能实现血浆胆固醇的有效降低。
