静脉注射到兔子体内的亚硫酸氢钠的代谢途径。
Metabolic pathways of sodium bisulfite injected intravenously in rabbits.
作者信息
Togawa T, Tanabe S, Kato M, Koshiishi I, Toida T, Imanari T
机构信息
Department of Analytical Chemistry, Meiji College of Pharmacy, Yato-cho Tanashi, Japan.
出版信息
J Pharmacobiodyn. 1990 Feb;13(2):83-9. doi: 10.1248/bpb1978.13.83.
The metabolites of sodium bisulfite in rabbits through intravenous injection were examined according to the high performance liquid chromatography method for determination of sulfur-containing substances. Most of the administered sulfite was oxidized to sulfate, and a small part was converted to thiosulfate, S-sulfoalbumin, S-sulfoglutathione and S-sulfocysteine. Furthermore, it was found that S-sulfocysteine administered intravenously to a rabbit was partially changed to inorganic sulfate and thiosulfate. These metabolites produced from sulfite in rabbits indicated the presence of the many and complicated metabolic pathways of sulfite in vivo.
按照用于测定含硫物质的高效液相色谱法，对通过静脉注射给予亚硫酸氢钠的兔子体内的代谢物进行了检测。大部分给予的亚硫酸盐被氧化成硫酸盐，一小部分转化为硫代硫酸盐、S-磺基白蛋白、S-磺基谷胱甘肽和S-磺基半胱氨酸。此外，还发现给兔子静脉注射S-磺基半胱氨酸后，其会部分转变为无机硫酸盐和硫代硫酸盐。兔子体内由亚硫酸盐产生的这些代谢物表明体内存在许多复杂的亚硫酸盐代谢途径。
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