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抗球蛋白抗体的刺激与特性研究。II. 用各种抗原免疫的兔血清中针对同源球蛋白和热变性自身血清抗原的抗球蛋白抗体

Studies on stimulation and properties of antiglobulin antibodies. II. Antiglobulin antibodies against homologous globulins and antigens of thermally denatured autologous sera in the sera of rabbits immunized with various antigens.

作者信息

Feluś E, Dudziak Z, Panek G, Nolewajka E, Achtelik W, Hendryk S

出版信息

Arch Immunol Ther Exp (Warsz). 1975;23(2):207-13.

PMID:238486
Abstract

Sera of 48 rabbits after long-term immunization with suspensions of Diplococcus pneumoniae, Klebsiella friedländeri, Proteus OX19 and solution of bovine albumin were examined for antibodies reacting with homologous gamma-globulins and antigens of thermally denatured autologous sera. Appearance of antibodies of this type was related to duration of immunization, but not related to the type of antigen used. The experimental results were explained as a result of altered antigenic properties of antibodies following reaction with homologous antigen.

摘要

对48只经肺炎双球菌、弗氏肺炎杆菌、变形杆菌OX19悬液及牛白蛋白溶液长期免疫的家兔血清进行检测,以寻找与同源γ-球蛋白及热变性自身血清抗原发生反应的抗体。这类抗体的出现与免疫持续时间有关,但与所用抗原类型无关。实验结果被解释为抗体与同源抗原反应后抗原特性发生改变的结果。

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