抗球蛋白抗体的刺激作用及特性研究。III. 合并呼吸道化脓性卡他的支气管哮喘患者中具有不同特异性的抗球蛋白抗体

Studies on stimulation and properties of antiglobulin antibodies. III. Antiglobulin antibodies with different specificity in patients with bronchial asthma complicated by suppurative catarrh of the respiratory tract.

作者信息

Dudziak Z, Feluś E, Rogala E, Panek G, Nolewajka E, Achtelik W, Hendryk S

出版信息

Arch Immunol Ther Exp (Warsz). 1975;23(3):353-9.

PMID:56160

Abstract

Sera from 14 of 50 patients suffering from bronchial asthma complicated by suppurative catarrh of the respiratory tract contained antibodies to homologous and heterologous gamma-globulins. The findings were attributed to hyperimmunization causing changed in antigenic properties of antibodies. Antigenically altered antibodies can act as autoimmunogenic stimuli inducing an immune response manifested by the appearance of antibodies to autologous gamma-globulins and cross reacting with homologous and heterologous gamma-globulins.

摘要

50例患有支气管哮喘合并呼吸道化脓性卡他的患者中，有14例的血清含有针对同源和异源γ球蛋白的抗体。这些发现归因于超免疫导致抗体抗原特性发生改变。抗原性改变的抗体可作为自身免疫原性刺激物，诱导以出现针对自身γ球蛋白的抗体并与同源和异源γ球蛋白发生交叉反应为表现的免疫应答。

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