Division of Oral and Maxillofacial Surgery, Schulich Medicine and Dentistry, Western University, London, Ontario, Canada.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Aug;116(2):214-20. doi: 10.1016/j.oooo.2013.05.008.
The object of this study was to determine the expression and localization of periostin in the major mixed odontogenic tumors and to correlate any differential staining of the mesenchymal components to the interrelationship of these tumors.
Five ameloblastic fibromas, 8 ameloblastic fibro-odontomas and 10 odontomas were assessed immunohistochemically for periostin staining. Because mesenchymal tissues were consistently present in all studied cases, these tissues were selected for statistical analysis of differential periostin staining.
Periostin was variably localized to the mesenchymal component of the tumors as well as to preameloblasts and ameloblasts. Analysis of the mesenchymal staining intensity was statistically significantly different between ameloblastic fibro-odontomas and odontomas (P < .001; Dunn multiple comparisons test).
Our results document periostin staining in human mixed odontogenic tumors. Statistical analysis of differential stromal staining supports the concept that the ameloblastic fibroma is a histogenetically distinct neoplasm as compared to ameloblastic fibro-odontoma and odontoma.
本研究旨在确定骨膜蛋白在主要混合性牙源性肿瘤中的表达和定位，并将间叶成分的任何差异染色与这些肿瘤的相互关系相关联。
对 5 例成釉细胞瘤纤维瘤、8 例成釉细胞瘤纤维牙瘤和 10 例牙瘤进行骨膜蛋白免疫组织化学染色。由于所有研究病例中均存在间质组织，因此选择这些组织进行骨膜蛋白染色差异的统计学分析。
骨膜蛋白在肿瘤的间叶成分以及前成釉细胞和成釉细胞中呈不同程度的定位。成釉细胞瘤纤维牙瘤和牙瘤之间的间质染色强度分析在统计学上有显著差异（P <.001；Dunn 多重比较检验）。
我们的结果证明了人类混合性牙源性肿瘤中的骨膜蛋白染色。差异基质染色的统计学分析支持成釉细胞瘤纤维瘤与成釉细胞瘤纤维牙瘤和牙瘤在组织发生上是不同的肿瘤的概念。
