Miyauchi M, Takata T, Ogawa I, Ito H, Nikai H, Ijuhin N, Tanimoto K, Miyauchi S
Department of Oral Pathology, Hiroshima University School of Dentistry, Japan.
J Oral Pathol Med. 1996 Feb;25(2):93-6. doi: 10.1111/j.1600-0714.1996.tb00200.x.
An ameloblastic fibro-odontoma which occurred in the mandible of a 3-year-old Japanese boy is reported together with immunohistochemical findings. Histologically, the tumor consisted of an ameloblastic fibroma-like area and some typical complex odontoma-like areas. The epithelial islands in the ameloblastic fibroma-like area showed different developmental stages of the epithelial-connective tissue interface. Immunohistochemical examination revealed that all epithelial components in the ameloblastic fibroma-like area showed expression of CK 8, CKs 13, 16, CK 14, CK 18 and CK 19, and coexpression of these cytokeratins and vimentin. These findings suggest that even the epithelial component without obvious epithelial-mesenchymal induction showed the final cell differentiation of the enamel organ with the potential for epithelial-mesenchymal induction.
本文报告了一例发生于一名3岁日本男孩下颌骨的成釉细胞纤维牙瘤，并展示了其免疫组化结果。组织学上，肿瘤由一个成釉细胞纤维瘤样区域和一些典型的复合性牙瘤样区域组成。成釉细胞纤维瘤样区域的上皮岛显示出上皮-结缔组织界面的不同发育阶段。免疫组化检查显示，成釉细胞纤维瘤样区域的所有上皮成分均表达CK 8、CKs 13、16、CK 14、CK 18和CK 19，且这些细胞角蛋白与波形蛋白共表达。这些结果表明，即使是没有明显上皮-间充质诱导的上皮成分，也显示出具有上皮-间充质诱导潜能的釉质器的最终细胞分化。
