认知和步态在普通人群中表现出明显的关联模式。
Cognition and gait show a distinct pattern of association in the general population.
机构信息
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
出版信息
Alzheimers Dement. 2014 May;10(3):328-35. doi: 10.1016/j.jalz.2013.03.009. Epub 2013 Jul 10.
BACKGROUND
With brain aging, cognition and gait deteriorate in several domains. However, the interrelationship between cognitive and gait domains remains unclear. We investigated the independent associations between cognitive and gait domains in a community-dwelling population.
METHODS
In the Rotterdam Study, 1232 participants underwent cognitive and gait assessment. Cognitive assessment included memory, information processing speed, fine motor speed, and executive function. Gait was summarized into seven independent domains: Rhythm, Variability, Phases, Pace, Tandem, Turning, and Base of Support. With multivariate linear regression, independent associations between cognitive and gait domains were investigated.
RESULTS
Information processing speed associated with Rhythm, fine motor speed with Tandem, and executive function with Pace. The effect sizes corresponded to a 5- to 10-year deterioration in gait.
CONCLUSIONS
Cognition and gait show a distinct pattern of association. These data accentuate the close, but complicated, relation between cognition and gait, and they may aid in unraveling the broader spectrum of the effects of brain aging.
背景
随着大脑老化，认知和步态在多个领域都会恶化。然而，认知和步态领域之间的相互关系尚不清楚。我们在一个社区人群中研究了认知和步态领域之间的独立关联。
方法
在鹿特丹研究中，1232 名参与者接受了认知和步态评估。认知评估包括记忆、信息处理速度、精细运动速度和执行功能。步态被总结为七个独立的领域：节奏、变异性、相位、步速、串联、转弯和支撑基础。通过多元线性回归，研究了认知和步态领域之间的独立关联。
结果
信息处理速度与节奏相关，精细运动速度与串联相关，执行功能与步速相关。这些效应大小相当于步态恶化 5-10 年。
结论
认知和步态表现出明显的关联模式。这些数据突出了认知和步态之间密切但复杂的关系，可能有助于揭示大脑老化更广泛的影响。
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