Shim Hayoung, Kim Miji, Won Chang Won
Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Department of Biomedical Science and Technology, College of Medicine, East-West Medical Research Institute, Kyung Hee University, Seoul, 02447, Republic of Korea.
Arch Gerontol Geriatr. 2020 Mar-Apr;87:103990. doi: 10.1016/j.archger.2019.103990. Epub 2019 Nov 19.
The motoric cognitive risk (MCR) syndrome, characterized by slow gait and cognitive complaints, is a high risk for transitioning to dementia. However, little is known regarding the cognitive profile among individuals with MCR. This study was performed to examine the association of MCR with cognitive functional domains.
We analyzed 2881 community-dwelling older adults aged 70-84 years (52 % women, mean age: 75.9 years) from the nationwide Korean Frailty and Aging Cohort Study. MCR was defined as the presence of subjective cognitive complaints and slow gait ≥ 1.0 standard deviations below age- and sex-specific means. Cognitive function was assessed using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet and the Frontal Assessment Battery.
A total of 231 participants met MCR criteria (prevalence = 8.02 %; 95 % confidence interval [CI]: 7.07-9.08 %). The prevalence of MCR did not increase with advancing age: 70-74 years, 8.90 %; 75-79 years, 7.06 %; and 80-84 years, 8.04 %; moreover, there were no sex-related differences. After adjusting for various confounders, MCR was associated with decline in global cognitive function, attention, processing speed and executive function (all P < 0.05). In particular, MCR was significantly associated with impairments in processing speed (odds ratio [OR]: 1.89, 95 % CI: 1.16-3.07) and executive function (OR: 1.94, 95 % CI: 1.28-2.93) (P > 0.05).
MCR was associated with deficits in global cognition, processing speed, and executive function, but not delayed free recall memory. Individuals with MCR had an increased risk of poor cognitive profile related to brain frontal and prefrontal function.
以步态缓慢和认知主诉为特征的运动认知风险（MCR）综合征是转变为痴呆症的高风险因素。然而，关于MCR个体的认知特征知之甚少。本研究旨在探讨MCR与认知功能领域之间的关联。
我们分析了来自韩国全国衰弱与老龄化队列研究的2881名年龄在70 - 84岁的社区居住老年人（52%为女性，平均年龄：75.9岁）。MCR被定义为主观认知主诉的存在以及步态缓慢≥低于年龄和性别特异性均值1.0个标准差。认知功能使用韩国版的阿尔茨海默病注册协会评估包和额叶评估量表进行评估。
共有231名参与者符合MCR标准（患病率 = 8.02%；95%置信区间[CI]：7.07 - 9.08%）。MCR的患病率并未随着年龄增长而增加：70 - 74岁，8.90%；75 - 79岁，7.06%；80 - 84岁，8.04%；此外，不存在性别差异。在调整各种混杂因素后，MCR与整体认知功能、注意力、处理速度和执行功能的下降相关（所有P < 0.05）。特别是，MCR与处理速度受损（优势比[OR]：1.89，95% CI：1.16 - 3.07）和执行功能受损（OR：1.94，95% CI：1.28 - 2.93）显著相关（P > 0.05）。
MCR与整体认知、处理速度和执行功能缺陷相关，但与延迟自由回忆记忆无关。MCR个体出现与脑额叶和前额叶功能相关的认知不良特征的风险增加。
