Hayashi T, Hiraiwa T, Kaneda M, Sakai T, Suzuki S, Katayama Y, Takao H, Yada K, Namikawa S, Yuasa H
Department of Surgery, Seicho National Hospital.
Kyobu Geka. 1990 Jun;43(6):457-61.
We have reported intrathoracic heart-lung transplantation in rats could be made easily by using Internal Shunt Method as described elsewhere. In this study, we examined the rejection of intrathoracic heart-lung allografts in this model to determine whether acute pulmonary rejection precedes cardiac rejection following heart-lung transplantation or not. Ten heart-lung allografts (no immunosuppressive agent was given) and four isografts were examined pathologically. There was no pathologic change except perivascular or peribronchiolar edema in isografts, which was attributed to operative damage. Acute pulmonary rejection apparent pathologically 3 days after transplantation and lung allografts lost its function 6 days after transplantation. Otherwise, acute cardiac rejection first became apparent pathologically 5 days after transplantation. And their pulsation appeared well 6 days after it. It is concluded that pulmonary rejection precedes cardiac rejection following heart-lung transplantation.
我们曾报道，采用别处所述的内分流法可轻松在大鼠中进行胸腔内心肺移植。在本研究中，我们检查了该模型中胸腔内心肺同种异体移植的排斥反应，以确定心肺移植后急性肺排斥是否先于心排斥发生。对10个心肺同种异体移植（未给予免疫抑制剂）和4个同基因移植进行了病理检查。同基因移植除血管周围或细支气管周围水肿外无病理变化，这归因于手术损伤。移植后3天病理上出现明显的急性肺排斥，肺同种异体移植在移植后6天失去功能。否则，急性心排斥在移植后5天病理上首次明显出现，并且在其出现6天后搏动良好。结论是心肺移植后肺排斥先于心排斥发生。
