Kitamura M, Hoyt H G, Starnes V A, Billingham M E, Koyanagi H
Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical College.
Kyobu Geka. 1994 Sep;47(10):809-11.
A new technique of intrathoracic half-working heart-lung transplantation in the rat was established. Donor heart-left lung graft was transplanted into left hemithorax of the recipient with aorta-aorta, bronchus-bronchus and superior vena cava (SVC)-SVC anastomoses, and the recipient's descending aorta proximal to the anastomosis was ligated. Five isografts (Lewis-Lewis) showed excellent cardiopulmonary function 4 weeks after transplantation. In 11 allografts (DA-Lewis), 5 rats without immunosuppression survived in 4-6 postoperative days and 6 rats with cyclosporine 10 mg/kg/day were alive during 8-14 days after operation. Nine of 11 allografts demonstrated moderate to severe (ISHLT grade 3-4) acute rejection and the grade of lung rejection was higher than that of heart rejection in 4 of 9 allografts.
建立了一种大鼠胸腔内半体心肺移植新技术。将供体心脏-左肺移植物移植到受体左半胸，进行主动脉-主动脉、支气管-支气管和上腔静脉-上腔静脉吻合，并结扎受体吻合口近端的降主动脉。5例同基因移植（Lewis-Lewis）在移植后4周显示出良好的心肺功能。在11例异基因移植（DA-Lewis）中，5只未接受免疫抑制的大鼠在术后4-6天存活，6只接受10mg/kg/天环孢素治疗的大鼠在术后8-14天存活。11例异基因移植中有9例表现为中度至重度（国际心脏和肺移植学会3-4级）急性排斥反应，9例中有4例肺排斥反应程度高于心脏排斥反应。
