Uchida K, Miyauchi Y, Nakayama H, Goto N
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.
Nihon Juigaku Zasshi. 1990 Jun;52(3):605-11. doi: 10.1292/jvms1939.52.605.
Amyloid angiopathy with cerebral hemorrhage and senile plaques was found in the brain of aged dogs. In all 9 cases examined, 13 to 19 years old, 6 males and 3 females, amyloid deposits were observed mostly in the wall of cerebral arterioles and capillaries showed hyaline degeneration. The accumulation of amyloid fibrils measuring about 10 nm in diameter was seen in the cerebral vessel wall by electron microscopy. The cerebral hemorrhage was observed in 6 of 9 dogs and 2 of them showed massive hemorrhage. The hemorrhagic foci were sometimes closely contact with the vessels involved in amyloid angiopathy. In addition, senile plaques being classified into 2 types were found in the cerebral cortex of 3 dogs. The first type was characterized by the accumulation of degenerative neurites and often contained granular argyrophilic material. The second type had a well-defined amyloid core with neuritic halo. Amyloid deposits were also found in or around intestinal vessel walls of 3 dogs. The amyloid deposited in the cerebral vessels, senile plaques and intestinal vessels showed characteristic green birefringence under the polarized light even after potassium permanganate treatment.
在老龄犬的大脑中发现了伴有脑出血和老年斑的淀粉样血管病。在所检查的全部9只犬（年龄为13至19岁，6只为雄性，3只为雌性）中，淀粉样沉积物主要见于脑小动脉壁，且毛细血管呈现透明变性。通过电子显微镜观察，在脑血管壁可见直径约10纳米的淀粉样纤维的积聚。9只犬中有6只出现脑出血，其中2只出现大量出血。出血灶有时与淀粉样血管病所累及的血管紧密相邻。此外，在3只犬的大脑皮质中发现了分为2种类型的老年斑。第一种类型的特征为退行性神经突的积聚，且常含有嗜银颗粒物质。第二种类型有一个界限分明的淀粉样核心及神经炎性晕。在3只犬的肠血管壁内或其周围也发现了淀粉样沉积物。即使经过高锰酸钾处理，沉积于脑血管、老年斑和肠血管中的淀粉样物质在偏振光下仍呈现特征性的绿色双折射。
