脊椎动物视网膜中穆勒胶质细胞介导的再生的比较分析。
A comparative analysis of Müller glia-mediated regeneration in the vertebrate retina.
作者信息
Gallina Donika, Todd Levi, Fischer Andy J
机构信息
Department of Neuroscience, College of Medicine, The Ohio State University, 4190 Graves Hall, 333 West 10th Ave, Columbus, OH 43210-1239, USA.
Department of Neuroscience, College of Medicine, The Ohio State University, 4190 Graves Hall, 333 West 10th Ave, Columbus, OH 43210-1239, USA.
出版信息
Exp Eye Res. 2014 Jun;123:121-30. doi: 10.1016/j.exer.2013.06.019. Epub 2013 Jul 9.
Abstract
This article reviews the current state of knowledge regarding the potential of Müller glia to become neuronal progenitor cells in the avian retina. We compare and contrast the remarkable proliferative and neurogenic capacity of Müller glia in the fish retina to the limited capacity of Müller glia in avian and rodent retinas. We summarize recent findings regarding the secreted factors, signaling pathways and cell intrinsic factors that have been implicated in the formation of Müller glia-derived progenitors. We discuss several key similarities and differences between the fish, rodent and chick model systems, highlighting several of the key transcription factors and signaling pathways that regulate the formation of Müller glia-derived progenitors.
摘要
本文综述了有关缪勒胶质细胞在鸟类视网膜中成为神经祖细胞潜力的当前知识状态。我们比较并对比了鱼类视网膜中缪勒胶质细胞显著的增殖和神经发生能力与鸟类和啮齿动物视网膜中缪勒胶质细胞有限的能力。我们总结了关于与缪勒胶质细胞衍生祖细胞形成相关的分泌因子、信号通路和细胞内在因子的最新发现。我们讨论了鱼类、啮齿动物和鸡模型系统之间的几个关键异同点，强调了一些调节缪勒胶质细胞衍生祖细胞形成的关键转录因子和信号通路。
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本文引用的文献
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Wnt signaling promotes Müller cell proliferation and survival after injury.Wnt 信号通路促进损伤后 Müller 细胞的增殖和存活。
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Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina.Stat3 定义了 Müller 胶质细胞的三个群体，并且在再生斑马鱼视网膜中起始最大程度的 Müller 胶质细胞增殖是必需的。
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