一种内源性芳香烃受体配体抑制人卵巢癌细胞的增殖和迁移。
An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.
机构信息
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, PR China.
Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI 53715, United States.
出版信息
Cancer Lett. 2013 Oct 28;340(1):63-71. doi: 10.1016/j.canlet.2013.06.026. Epub 2013 Jul 9.
Abstract
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor mediates many biological processes. Herein, we investigated if 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE, an endogenous AhR ligand) regulated proliferation and migration of human ovarian cancer cells via AhR. We found that AhR was widely present in many histotypes of ovarian cancer tissues. ITE suppressed OVCAR-3 cell proliferation and SKOV-3 cell migration in vitro, which were blocked by AhR knockdown. ITE also suppressed OVCAR-3 cell growth in mice. These data suggest that the ITE might potentially be used for therapeutic intervention for at least a subset of human ovarian cancer.
摘要
芳基烃受体 (AhR) 是一种配体激活的转录因子，介导许多生物学过程。在此，我们研究了 2-(1’H-吲哚-3’-羰基)-噻唑-4-羧酸甲酯 (ITE，一种内源性 AhR 配体) 是否通过 AhR 调节人卵巢癌细胞的增殖和迁移。我们发现 AhR 在许多卵巢癌组织的组织类型中广泛存在。ITE 在体外抑制 OVCAR-3 细胞增殖和 SKOV-3 细胞迁移，而 AhR 敲低则阻断了这种作用。ITE 还抑制了小鼠的 OVCAR-3 细胞生长。这些数据表明，ITE 可能有望用于至少一部分人类卵巢癌的治疗干预。
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