Department of Gynecology and Obstetrics, West China Second University Hospital, Chengdu, China.
Int J Gynecol Cancer. 2013 Sep;23(7):1184-90. doi: 10.1097/IGC.0b013e31829ee012.
We pooled the data from published studies to estimate the prognostic value of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/computed tomography (CT) in cervical cancer patients.
We searched MEDLINE, EMBASE, and PUBMED to identify studies investigating the association of 18F-FDG PET or PET/CT with clinical survival outcomes of patients with cervical cancer. The summarized hazard ratio (HR) was estimated by using fixed- or random-effect model according to heterogeneity between trails.
We analyzed a total number of 1854 patients from 16 studies and found that positive pretreatment FDG-PET images were significantly associated with poorer event-free survival (hazard ratio [HR], 2.681; 95% confidence interval [CI], 2.059-3.490) and overall survival (HR, 2.063; 95% CI, 1.023-4.158). Furthermore, metabolic response of therapy as shown on posttreatment PET images was also capable of predicting event-free survival and overall survival with statistical significance, and the HR was 2.030 (95% CI, 1.537-2.681) and 2.322 (95% CI, 1.485-3.630), respectively.
Uptake of 18F-FDG on PET or PET/CT either before or after treatment has a promising value of both predicting survival outcomes for patients with cervical cancer and identifying patients for more aggressive treatment.
我们汇集已发表研究的数据，以评估氟-18-氟代脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）或 PET/计算机断层扫描（CT）在宫颈癌患者中的预后价值。
我们检索了 MEDLINE、EMBASE 和 PUBMED，以确定研究 18F-FDG PET 或 PET/CT 与宫颈癌患者临床生存结局之间关联的研究。根据试验之间的异质性，使用固定或随机效应模型估计汇总风险比（HR）。
我们分析了来自 16 项研究的 1854 名患者，发现预处理 FDG-PET 图像阳性与无事件生存（风险比 [HR]，2.681；95%置信区间 [CI]，2.059-3.490）和总生存（HR，2.063；95%CI，1.023-4.158）显著相关。此外，治疗后 PET 图像上的代谢反应也能够预测无事件生存和总生存，具有统计学意义，HR 分别为 2.030（95%CI，1.537-2.681）和 2.322（95%CI，1.485-3.630）。
治疗前后 18F-FDG 在 PET 或 PET/CT 上的摄取对预测宫颈癌患者的生存结局和识别需要更积极治疗的患者具有很好的价值。
