Xuan Dongchun, Wen Weibo, Tian Shengri, Piao Minhu, Xu Dongyuan, Liu Lan
Center of Morphological Experiment, Medical College of Yanbian University.
Department of Nuclear Medicine.
Medicine (Baltimore). 2020 May;99(20):e19988. doi: 10.1097/MD.0000000000019988.
We present a comprehensive systematic review of the documented literature on parameters derived from F-fluorodeoxyglucose positron emission tomography (F-FDG PET) and meta-analysis of the prognostic value of maximal standard uptake value (SUVmax), metabolic tumor volume (MTV) and total lesional glycolysis (TLG) in patients with renal carcinoma (RCC).
Relevant articles in English from PubMed, EMBASE, and the Cochrane Library were retrieved. Pooled hazard ratio (HR) values were used to assess the prognostic value of SUVmax, MTV, and TLG.
A total of 10 primary studies involving 780 patients with RCC were included. The combined HRs for event-free survival were 1.32 (95% CI 1.10-1.58) for SUVmax, 2.40 (95% CI 1.20-4.79) for MTV, and 3.31 (95% CI 1.68-6.50) for TLG. Pooled HRs for overall survival were 1.264 (95% CI 1.124-1.421) for SUVmax, 3.52 (95% CI 1.451-8.536) for MTV, and 6.33 (95% CI 1.32-30.30) for TLG. Subgroup analysis revealed SUVmax as an independent risk factor for patients with recurrence or metastasis.
The present meta-analysis confirmed that despite the clinical heterogeneity of RCC and adoption of various methods between studies, high SUVmax is a significant prognostic factor, especially in patients with recurrence or metastasis. MTV and TLG were associated with prediction of higher risk of adverse events or death in patients with RCC.
我们对源自氟脱氧葡萄糖正电子发射断层扫描（F-FDG PET）的参数的文献进行了全面的系统评价，并对最大标准摄取值（SUVmax）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）在肾癌（RCC）患者中的预后价值进行了荟萃分析。
检索了PubMed、EMBASE和Cochrane图书馆中用英文发表的相关文章。采用合并风险比（HR）值评估SUVmax、MTV和TLG的预后价值。
共纳入10项涉及780例RCC患者的初步研究。SUVmax的无事件生存合并HR为1.32（95%CI 1.10-1.58），MTV为2.40（95%CI 1.20-4.79），TLG为3.31（95%CI 1.68-6.50）。SUVmax的总生存合并HR为1.264（95%CI 1.124-1.421），MTV为3.52（95%CI 1.451-8.536），TLG为6.33（95%CI 1.32-30.30）。亚组分析显示SUVmax是复发或转移患者的独立危险因素。
本荟萃分析证实，尽管RCC存在临床异质性且各研究采用的方法不同，但高SUVmax是一个重要的预后因素，尤其是在复发或转移患者中。MTV和TLG与RCC患者不良事件或死亡风险较高的预测相关。
