Centre for Mental Health, Addiction and Suicide Research, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Road, Bristol BS8 2BN, UK and.
Fam Pract. 2013 Dec;30(6):705-11. doi: 10.1093/fampra/cmt028. Epub 2013 Jul 12.
Adequate recruitment and retention rates are vital to achieving a successful randomized controlled trial. Historically this has been particularly challenging in mental health research. Few researchers have explored patients' reasons for taking part and remaining in a depression trial.
To explore patients' reasons for taking part and remaining in a trial that aimed to assess the effectiveness of cognitive behavioural therapy (CBT) as an adjunct to usual care for primary care patients with treatment resistant depression.
(i)
Patients completed a short exit questionnaire about their experiences of taking part in the CoBalT trial. In addition, 40 semi-structured telephone interviews were conducted with a purposive sample of these patients to further explore their experiences. (ii)
General practices, England and Scotland.
Of 469 patients randomized into the trial, 302 (64.4%) completed an exit questionnaire. The most frequently rated reason for taking part in the study were 'I was willing to try anything that might help me feel better' (66%). Patients indicated in interviews why they preferred follow-up data to be collected on a face-to-face basis rather than over the telephone. Some patients reported that taking part in the trial gave them a sense of self-worth and accomplishment.
Patients felt they benefited from being in the trial because it enabled them to reflect on their feelings. For some, taking part increased their feelings of self-worth. These findings may be applicable to trials where feelings of inclusion and being valued are likely to promote continued participation.
充分的招募和保留率对于成功进行随机对照试验至关重要。在心理健康研究中，这一目标历来具有挑战性。很少有研究人员探讨过患者参与和留在抑郁试验中的原因。
探讨患者参与并留在一项旨在评估认知行为疗法（CBT）作为辅助常规护理治疗治疗抵抗性抑郁症的初级保健患者的有效性的试验中的原因。
（i）
患者完成了一份简短的退出问卷，内容涉及他们参与 CoBalT 试验的经历。此外，对这些患者进行了 40 次有针对性的半结构化电话访谈，以进一步探讨他们的经历。（ii）
英格兰和苏格兰的普通诊所。
在随机分配到试验中的 469 名患者中，有 302 名（64.4%）完成了退出问卷。参与研究的最常被评价的原因是“我愿意尝试任何可能帮助我感觉更好的方法”（66%）。患者在访谈中表示了为什么他们更喜欢面对面而不是通过电话收集随访数据。一些患者报告说，参与试验使他们感到自我价值和成就感。
患者认为他们从试验中受益，因为这使他们能够反思自己的感受。对一些人来说，参与增加了他们的自我价值感。这些发现可能适用于那些感觉被包容和被重视的试验，因为这可能会促进持续参与。
