Suminaga Y, Yasuda Y
Department of Surgery, Jichi Medical School, Tochigi, Japan.
Nihon Geka Gakkai Zasshi. 1990 May;91(5):594-604.
The effect of hepatectomy and administration of glucagon on hepatic hemodynamics were studied using mongrel dogs. The results were as follows: 1) Hepatic blood flow in the 70% hepatectomized dogs was significantly less than that in dogs subjected to sham operation or 40% hepatectomy. 2) Bolus injection of glucagon (10 micrograms/kg) increased blood flow in the hepatectomized dogs as well as that in the control dogs. The percentage increment, however, was significantly smaller in the 70% hepatectomized dogs, possibly due to little increase of portal vein blood flow. 3) Portal vein pressure and its resistance were significantly higher in the 70% hepatectomized dogs than in both the 40% hepatectomized dogs and the control dogs. 4) Although pre-sinusoidal resistance showed no significant difference among these three groups, post-sinusoidal resistance increased stepwise in the order of extent of hepatectomy. These results suggest that administration of glucagon after extended major hepatectomy is not so particularly effective in generating adequate hepatic tissue blood flow.
利用杂种犬研究了肝切除术和注射胰高血糖素对肝脏血流动力学的影响。结果如下：1）70%肝切除犬的肝血流量显著低于假手术犬或40%肝切除犬。2）静脉推注胰高血糖素（10微克/千克）可增加肝切除犬和对照犬的血流量。然而，70%肝切除犬血流量增加的百分比明显较小，这可能是由于门静脉血流量增加较少所致。3）70%肝切除犬的门静脉压力及其阻力显著高于40%肝切除犬和对照犬。4）尽管这三组之间的窦前阻力无显著差异，但窦后阻力随肝切除范围的增加而逐步增加。这些结果表明，扩大的大肝切除术后注射胰高血糖素在产生足够的肝组织血流量方面并非特别有效。
