Yasuda Y
Nihon Geka Gakkai Zasshi. 1987 Jan;88(1):63-73.
Loading of glucagon on mongrel dogs was performed and the following results were obtained: The effects of glucagon on hemodynamics were decrease in the vascular resistance and increase in the blood flow in the superior mesenteric artery. Therefore, the blood flow of the portal vein was also increased. In the hepatic artery, glucagon also decreased the vascular resistance, when the blood flow was initially increased and then decreased. This might be attributable to the difference in sensitivity between the vascular resistance by glucagon. While administration of glucagon increased the blood flow of the portal vein, it had less effect on the vascular resistance. Though the blood flow of the hepatic tissues by hydrogen gas clearance method correlated favorably with the hepatic inflow measured with electromagnetic flowmeter, local blood flow in the hepatic tissues was not always constant in the liver and had some difference. Concerning change in local blood flow in the hepatic tissues, in low perfusion area, the blood flow was increased by low concentration of glucagon. This change in distribution of the blood flow was presumed to be caused by the portal flow. After simultaneous loading of glucagon and ICG, glucagon accelerated excretion of ICG. After simultaneous loading of glucagon and ICG on cirrhotic and control patients, accelerated excretion of ICG with time course was observed in control group. On the other hand, slightly accelerated excretion was seen in cirrhotics. It was suggested that simultaneous loading test of glucagon and ICG may be useful as a test for dynamic ability of hepatic circulation which can not be obtained by ICG loading test.
对杂种犬进行了胰高血糖素负荷试验，结果如下：胰高血糖素对血流动力学的影响是血管阻力降低，肠系膜上动脉血流增加。因此，门静脉血流也增加。在肝动脉中，胰高血糖素也降低了血管阻力，起初血流增加，随后减少。这可能归因于胰高血糖素对血管阻力的敏感性差异。虽然给予胰高血糖素增加了门静脉血流，但对血管阻力的影响较小。尽管通过氢气清除法测得的肝组织血流与用电磁流量计测得的肝内血流密切相关，但肝组织内的局部血流在肝脏中并不总是恒定的，存在一些差异。关于肝组织局部血流的变化，在低灌注区域，低浓度的胰高血糖素可使血流增加。这种血流分布的变化被认为是由门静脉血流引起的。胰高血糖素和吲哚菁绿（ICG）同时负荷后，胰高血糖素加速了ICG的排泄。在肝硬化患者和对照组同时负荷胰高血糖素和ICG后，对照组观察到ICG排泄随时间进程加速。另一方面，肝硬化患者排泄略有加速。提示胰高血糖素和ICG同时负荷试验可能作为一种检测肝循环动态能力的试验，而这是ICG负荷试验无法获得的。
