α,α-二烷基-β-氧代酰胺和二甲亚砜甲基叶立德的[4+1]环化反应：β-羟基-γ-内酰胺的合成途径。

Formal [4+1] annulation of α,α-dialkyl β-oxo amides and dimethylsulfoxonium methylide: a synthetic route to β-hydroxy-γ-lactams.

机构信息

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

出版信息

Chem Commun (Camb). 2013 Aug 25;49(66):7358-60. doi: 10.1039/c3cc43317j.

Abstract

A facile and efficient one-pot synthesis of β-hydroxy-γ-lactams from α,α-dialkyl β-oxo amides and trimethylsulfoxonium iodide in the presence of sodium hydride via a tandem Corey-Chaykovsky reaction and an intramolecular lactamization process is developed.

摘要

本文报道了一种在氢化钠存在下，通过串联 Corey-Chaykovsky 反应和分子内内酯化过程，由α,α-二烷基β-氧代酰胺和三甲基碘化亚砜一锅法高效合成β-羟基-γ-内酰胺的方法。