• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The effect of pentachlorophenol and its metabolite tetrachlorohydroquinone on cell growth and the induction of DNA damage in Chinese hamster ovary cells.

作者信息

Ehrlich W

机构信息

Institut für Biochemie und Molekularbiologie, Freie Universität Berlin, Germany.

出版信息

Mutat Res. 1990 Aug;244(4):299-302. doi: 10.1016/0165-7992(90)90076-v.

DOI:10.1016/0165-7992(90)90076-v
PMID:2385245
Abstract

It is shown that p-tetrachlorohydroquinone (TCH), the metabolite of the environmental chemical pentachlorophenol (PCP), is more toxic to cultured CHO cells than PCP, and that it causes DNA single-strand breaks and/or alkali-labile sites at concentrations of 2-10 microgram/ml as demonstrated by the alkaline elution technique.

摘要

相似文献

1
The effect of pentachlorophenol and its metabolite tetrachlorohydroquinone on cell growth and the induction of DNA damage in Chinese hamster ovary cells.
Mutat Res. 1990 Aug;244(4):299-302. doi: 10.1016/0165-7992(90)90076-v.
2
DNA-damaging properties and cytotoxicity in human fibroblasts of tetrachlorohydroquinone, a pentachlorophenol metabolite.五氯苯酚代谢物四氯对苯二酚对人成纤维细胞的DNA损伤特性及细胞毒性
Mutat Res. 1985 Jan-Mar;145(1-2):71-5. doi: 10.1016/0167-8817(85)90042-2.
3
The effect of pentachlorophenol and its metabolite tetrachlorohydroquinone on RNA, protein, and ribosome synthesis in Saccharomyces cells.五氯苯酚及其代谢产物四氯对苯二酚对酿酒酵母细胞中RNA、蛋白质和核糖体合成的影响。
Ecotoxicol Environ Saf. 1987 Feb;13(1):7-12. doi: 10.1016/0147-6513(87)90037-6.
4
Induction of micronuclei in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol.
Mutat Res. 1992 Jun 1;279(3):205-8. doi: 10.1016/0165-1218(92)90068-b.
5
Oxidative DNA lesions in V79 cells mediated by pentachlorophenol metabolites.五氯苯酚代谢物介导的V79细胞中的氧化性DNA损伤
Arch Toxicol. 1996;70(7):457-60. doi: 10.1007/s002040050299.
6
Hexachlorobenzene and its metabolites pentachlorophenol and tetrachlorohydroquinone: interaction with thyroxine binding sites of rat thyroid hormone carriers ex vivo and in vitro.六氯苯及其代谢产物五氯苯酚和四氯对苯二酚：离体和体外与大鼠甲状腺激素载体的甲状腺素结合位点的相互作用。
Toxicol Lett. 1991 Dec;59(1-3):101-7. doi: 10.1016/0378-4274(91)90060-j.
7
Induction of 8-hydroxy-2-deoxyguanosine and single-strand breaks in DNA of V79 cells by tetrachloro-p-hydroquinone.四氯对苯二酚对V79细胞DNA中8-羟基-2-脱氧鸟苷和单链断裂的诱导作用。
Mutat Res. 1995 Jun;329(1):29-36. doi: 10.1016/0027-5107(95)00014-a.
8
Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants.五氯苯酚（PCP）及其代谢物四氯对苯二酚（TCHQ）对肝细胞的细胞毒性作用受到抗氧化剂的调节。
Cell Biol Toxicol. 2014 Aug;30(4):233-52. doi: 10.1007/s10565-014-9283-4. Epub 2014 Jul 5.
9
Role of active oxygen species in DNA damage by pentachlorophenol metabolites.活性氧物种在五氯苯酚代谢产物所致DNA损伤中的作用。
Mutat Res. 1994 Oct 1;310(1):79-88. doi: 10.1016/0027-5107(94)90011-6.
10
Oxidative stress and liver toxicity in rats and human hepatoma cell line induced by pentachlorophenol and its major metabolite tetrachlorohydroquinone.五氯苯酚及其主要代谢产物四氯对苯二酚对大鼠和人肝癌细胞系的氧化应激和肝毒性
Toxicol Lett. 2001 Jun 20;122(2):157-69. doi: 10.1016/s0378-4274(01)00361-7.

引用本文的文献

1
Evidence of apoptosis in some cell types due to pentachlorophenol (PCP) in Heteropneustes fossilis.证明五氯苯酚（PCP）会导致褐牙鲆某些细胞类型发生细胞凋亡。
Saudi J Biol Sci. 2013 Jan;20(1):45-9. doi: 10.1016/j.sjbs.2012.10.002. Epub 2012 Oct 27.
2
Effects of pentachlorophenol and tetrachlorohydroquinone on mitogen-activated protein kinase pathways in Jurkat T cells.五氯苯酚和四氯对苯二酚对Jurkat T细胞中丝裂原活化蛋白激酶途径的影响。
Environ Health Perspect. 2002 Feb;110(2):139-43. doi: 10.1289/ehp.02110139.
3
In vivo levels of chlorinated hydroquinones in a pentachlorophenol-degrading bacterium.
五氯苯酚降解菌中氯代对苯二酚的体内水平
Appl Environ Microbiol. 1997 May;63(5):1883-8. doi: 10.1128/aem.63.5.1883-1888.1997.
4
Growth responses of achlorophyllous Euglena gracilis to selected concentrations of cadmium and pentachlorophenol.无叶绿素的纤细裸藻对选定浓度镉和五氯苯酚的生长反应。
Arch Environ Contam Toxicol. 1995 Jan;28(1):8-12. doi: 10.1007/BF00213962.