Witte I, Juhl U, Butte W
Mutat Res. 1985 Jan-Mar;145(1-2):71-5. doi: 10.1016/0167-8817(85)90042-2.
The DNA-damaging potential of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCH) was investigated. TCH was found to bind covalently to calf-thymus DNA and to cause single-strand breaks in PM2 DNA. No DNA-damaging effects were observed for PCP. Exposure of human fibroblasts to PCP and TCH showed that TCH is more toxic, when colony-forming ability after exposure to the agent is used as a measure of toxicity. In the evaluation of the mutagenic and carcinogenic potential of PCP the metabolite TCH should be taken into consideration.
研究了五氯苯酚（PCP）及其代谢物四氯对苯二酚（TCH）的DNA损伤潜力。发现TCH能与小牛胸腺DNA共价结合，并导致PM2 DNA出现单链断裂。未观察到PCP有DNA损伤作用。将人成纤维细胞暴露于PCP和TCH中发现，以暴露于该试剂后的集落形成能力作为毒性衡量指标时，TCH的毒性更强。在评估PCP的诱变和致癌潜力时，应考虑其代谢物TCH。
