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婴儿期经胸廓切开术行主动脉缩窄手术修复后再缩窄相关因素

Factors associated with recoarctation after surgical repair of coarctation of the aorta by way of thoracotomy in young infants.

作者信息

Truong Dongngan T, Tani Lloyd Y, Minich L LuAnn, Burch Phillip T, Bardsley Tyler R, Menon Shaji C

机构信息

University of Utah, Salt Lake City, UT, USA.

出版信息

Pediatr Cardiol. 2014 Jan;35(1):164-70. doi: 10.1007/s00246-013-0757-6. Epub 2013 Jul 13.

Abstract

Echocardiography is the mainstay of preoperative arch imaging in infants with coarctation of the aorta. In simple coarctation, repair by way of sternotomy or thoracotomy is often determined by echocardiographic transverse arch measurements. The degree of arch hypoplasia that is prohibitive to repair by way of thoracotomy is unknown. Clinical predictors of recoarctation are also unknown. Demographic, echocardiographic (transverse arch and aortic measurements), operative, and postoperative data of infants <90 days old with simple coarctation repaired by way of thoracotomy between February 2005 and November 2011 were evaluated. Recoarctation was defined as surgical or catheter reintervention after hospital discharge. Eighty-four infants underwent coarctation repair at median age of 12 (range 1-85) days with median follow-up of 12.3 (range 0.5-71.9) months. The seven (8 %) infants with recoarctation underwent balloon angioplasty. In multivariable analysis, only greater postoperative Doppler peak velocity [1.13, confidence interval (CI) 1.04-1.23] and greater sinotubular junction z-score (hazard ratio 4.19, CI 1.47-11.95) independently predicted coarctation. Doppler peak velocity >2.12 m/s had sensitivity of 63 % and specificity of 83 % of predicting recoarctation, and ST junction z-score >-0.93 had sensitivity of 100 % and specificity of 58 %. No transverse arch dimensions were independently associated with recoarctation. Infants with transverse arch z-score as low as -2.8 underwent successful repair by way of thoracotomy. No clinical predictors were significant.

摘要

超声心动图是主动脉缩窄婴儿术前主动脉弓成像的主要手段。在单纯性主动脉缩窄中,通过胸骨切开术或开胸手术进行修复通常由超声心动图测量的主动脉弓横径决定。开胸手术无法进行修复的主动脉弓发育不全程度尚不清楚。再狭窄的临床预测因素也不清楚。对2005年2月至2011年11月间接受开胸手术修复的年龄小于90天的单纯性主动脉缩窄婴儿的人口统计学、超声心动图(主动脉弓横径和主动脉测量)、手术及术后数据进行了评估。再狭窄定义为出院后进行手术或导管介入治疗。84例婴儿接受了主动脉缩窄修复,中位年龄为12(范围1 - 85)天,中位随访时间为12.3(范围0.5 - 71.9)个月。7例(8%)再狭窄婴儿接受了球囊血管成形术。在多变量分析中,只有术后较高的多普勒峰值速度[1.13,置信区间(CI)1.04 - 1.23]和较高的窦管交界z评分(风险比4.19,CI 1.47 - 11.95)独立预测主动脉缩窄。多普勒峰值速度>2.12 m/s预测再狭窄的敏感性为63%,特异性为83%,窦管交界z评分>-0.93预测再狭窄的敏感性为100%,特异性为58%。没有主动脉弓横径尺寸与再狭窄独立相关。主动脉弓z评分低至-2.8的婴儿通过开胸手术成功修复。没有临床预测因素具有显著性。

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