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广泛解剖和肋间血管离断可通过开胸手术修复主动脉弓发育不全。

Wide Dissection and Intercostal Vessel Division Allows for Repair of Hypoplastic Aortic Arch Through Thoracotomy.

作者信息

Sandoval Néstor F, Acevedo Catalina Vargas, Umaña Juan Bernardo, Pineda Ivonne, Guerrero Albert, Obando Carlos, Umaña Juan P, Camacho Jaime

机构信息

1 Congenital Heart Disease Institute, Fundación Cardioinfantil, Instituto de Cardiología, Bogotá, Colombia.

2 Research Department, Fundación Cardioinfantil, Instituto de Cardiología, Bogotá, Colombia.

出版信息

World J Pediatr Congenit Heart Surg. 2018 Nov;9(6):659-664. doi: 10.1177/2150135118799631.

Abstract

BACKGROUND

The approach to coarctation of the aorta with hypoplastic aortic arch is controversial. We evaluated the outcomes in patients with coarctation of the aorta with or without hypoplastic aortic arch operated through a posterior left lateral thoracotomy.

METHODS

A retrospective cohort of patients with aortic coarctation, who underwent repair between January 2009 and October 2017, was analyzed. Preoperative, postoperative, and echocardiographic characteristics were reviewed. Statistical analysis examined survival, freedom from reintervention, and freedom from recoarctation.

RESULTS

In nine years, 389 patients who underwent surgical treatment for coarctation of the aorta were identified; after exclusion criteria and complete echocardiographic reports, 143 patients were analyzed, of which 29 patients had hypoplastic aortic arch. The modification in the extended end-to-end anastomosis technique was a wide dissection and mobilization of the descending aorta that was achieved due to the ligation and division of 3 to 5 intercostal vessels. In both groups, patients were close to one month of age and had a median weight of 3.6 and 3.4 kg for hypoplastic and nonhypoplastic arch, respectively. In postoperative events, there was no statistically significant difference between the groups ( P = .57 for renal failure, P = .057 for transient, nonpermanent neurologic events, P = .496 for sepsis), as for intensive care unit ( P = .502) and total in-hospital stay ( P = .929). There was one case of postoperative mortality in each group and both were associated with noncardiac comorbidities. Regarding survival (log-rank = 0.060), freedom from reintervention (log-rank = 0.073), and freedom from recoarctation (log-rank = 0.568), there was no statistically significant difference between the groups.

CONCLUSION

We believe that it is the modified technique that allowed greater mobilization of the aorta and successful repair of hypoplastic arch through thoracotomy, without an increase in paraplegia or other adverse outcomes.

摘要

背景

主动脉缩窄合并主动脉弓发育不全的治疗方法存在争议。我们评估了通过左后外侧开胸手术治疗的主动脉缩窄患者(无论是否合并主动脉弓发育不全)的治疗效果。

方法

对2009年1月至2017年10月期间接受主动脉缩窄修复手术的患者进行回顾性队列分析。回顾术前、术后及超声心动图特征。统计分析评估生存率、再次干预率及再缩窄率。

结果

9年间,共确定389例接受主动脉缩窄手术治疗的患者;经排除标准及完整的超声心动图报告后,分析了143例患者,其中29例患者合并主动脉弓发育不全。改良的端端吻合技术改进在于广泛解剖并游离降主动脉,这是通过结扎并切断3至5支肋间血管实现的。两组患者年龄均接近1个月,主动脉弓发育不全组和非发育不全组患者的体重中位数分别为3.6 kg和3.4 kg。术后事件方面,两组之间无统计学显著差异(肾衰竭P = .57,短暂性非永久性神经系统事件P = .057,脓毒症P = .496),重症监护病房住院时间(P = .502)及总住院时间(P = .929)亦无显著差异。每组各有1例术后死亡病例,均与非心脏合并症有关。在生存率(对数秩检验= 0.060)、再次干预率(对数秩检验= 0.073)及再缩窄率(对数秩检验= 0.568)方面,两组之间无统计学显著差异。

结论

我们认为,正是改良技术使得主动脉得以更大程度地游离,并通过开胸手术成功修复发育不全的主动脉弓,且并未增加截瘫或其他不良后果的发生率。

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