IEEE Trans Biomed Circuits Syst. 2008 Mar;2(1):10-21. doi: 10.1109/TBCAS.2008.918285.
To fully exploit the recording capabilities provided by current and future generations of multi-electrode arrays, some means to eliminate the residual charge and subsequent artifacts generated by stimulation protocols is required. Custom electronics can be used to achieve such goals, and by making them scalable, a large number of electrodes can be accessed in an experiment. In this work, we present a system built around a custom 16-channel IC that can stimulate and record, within 3 ms of the stimulus, on the stimulating channel, and within 500 mus on adjacent channels. This effectiveness is achieved by directly discharging the electrode through a novel feedback scheme, and by shaping such feedback to optimize electrode behavior. We characterize the different features of the system that makes such performance possible and present biological data that show the system in operation. To enable this characterization, we present a framework for measuring, classifying, and understanding the multiple sources of stimulus artifacts. This framework facilitates comparisons between artifact elimination methodologies and enables future artifact studies.
为了充分利用当前和未来几代多电极阵列提供的记录能力，需要一些方法来消除刺激协议产生的残余电荷和后续伪迹。定制电子设备可用于实现这些目标，并且通过使其可扩展，可以在实验中访问大量电极。在这项工作中，我们提出了一个系统，该系统围绕一个定制的 16 通道 IC 构建，可以在刺激后 3 毫秒内在刺激通道上进行刺激和记录，并且在相邻通道上可以在 500 微秒内进行记录。通过直接通过新颖的反馈方案对电极进行放电，并通过对这种反馈进行整形来优化电极行为，从而实现这种有效性。我们描述了使这种性能成为可能的系统的不同特征，并展示了显示系统运行情况的生物学数据。为了实现这种表征，我们提出了一种用于测量、分类和理解多种刺激伪迹源的框架。该框架便于比较消除伪迹的方法，并支持未来的伪迹研究。
