Yale School of Public Health, New Haven, CT, USA.
J Med Virol. 2013 Sep;85(9):1602-10. doi: 10.1002/jmv.23613.
Risk of Kaposi sarcoma (KS) is linked to detection of Kaposi sarcoma-associated herpesvirus (KSHV) DNA in plasma, but little is known about the prevalence and risk factors for plasma KSHV DNA detection among the general population where KS is endemic. Correlates of KSHV plasma detection were investigated in a population-based sample of adult Ugandans (15-59 years) who participated in an HIV/AIDS serobehavioral survey in 2004/2005. KSHV DNA was measured in plasma of 1,080 KSHV seropositive and 356 KSHV seronegative persons using polymerase chain reaction (PCR). KSHV DNA in plasma was detected in 157 (8.7%) persons; of these 149 (95%) were KSHV seropositive and 8 (5%) were seronegative. Detection of KSHV DNA in plasma was significantly associated with male sex (P < 0.001), older age (P = 0.003), residence in a rural versus urban area (P = 0.002), geographic region (P = 0.02), and being KSHV seropositive (13.8% seropositive vs. 2.3% seronegative, P < 0.001). In a multivariable model, KSHV DNA plasma quantity was significantly higher in men (P = 0.002), inversely associated with age (P = 0.05), and residing in an urban area (P = 0.01). In Uganda, KSHV is detected more frequently in the plasma of adult males and residents of rural regions, potentially explaining the increased risk of KS in these subsets of the Ugandan population.
卡波济肉瘤（KS）的风险与血浆中卡波济肉瘤相关疱疹病毒（KSHV）DNA 的检测有关，但在 KS 流行的普通人群中，关于血浆 KSHV DNA 检测的流行率和危险因素知之甚少。本研究在 2004/2005 年参加艾滋病毒/艾滋病血清学行为调查的乌干达成年人群（15-59 岁）中进行了一项基于人群的样本研究，调查了 KSHV 血浆检测的相关因素。使用聚合酶链反应（PCR）对 1080 名 KSHV 血清阳性和 356 名 KSHV 血清阴性者的血浆中的 KSHV DNA 进行了测量。在 157 名（8.7%）人中检测到了血浆中的 KSHV DNA；其中 149 名（95%）为 KSHV 血清阳性，8 名（5%）为血清阴性。血浆中 KSHV DNA 的检测与男性（P<0.001）、年龄较大（P=0.003）、居住在农村地区而非城市地区（P=0.002）、地理位置（P=0.02）以及 KSHV 血清阳性（13.8%的血清阳性者比 2.3%的血清阴性者，P<0.001）显著相关。在多变量模型中，男性血浆中 KSHV DNA 量明显更高（P=0.002），与年龄呈负相关（P=0.05），且居住在城市地区（P=0.01）。在乌干达，成年男性和农村地区居民的血浆中更频繁地检测到 KSHV，这可能解释了乌干达人群中这些亚组 KS 风险增加的原因。
