First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.
Cell Biol Int. 2013 Nov;37(11):1190-6. doi: 10.1002/cbin.10152. Epub 2013 Aug 5.
Kaempferol is a dietary flavonoid that can function as a selective estrogen receptor modulator (SERM). Estrogen-related receptors alpha and gamma (ERRα and ERRγ) are orphan nuclear receptors that play important roles in mitochondrial biogenesis and cancer development. We have shown that kaempferol can functionally antagonize the activities of ERRs based on both response element reporter systems and target gene analysis. Kaempferol modulation of mitochondrial function and suppression cancer cell growth has been confirmed. These findings suggest that kaempferol may exert their anti-cancer activities through antagonizing ERRs activities.
山柰酚是一种膳食类黄酮，可作为选择性雌激素受体调节剂（SERM）。雌激素相关受体α和γ（ERRα和 ERRγ）是孤儿核受体，在线粒体生物发生和癌症发展中发挥重要作用。我们已经证明，山柰酚可以通过反应元件报告系统和靶基因分析来拮抗 ERR 的功能。山柰酚对线粒体功能的调节和抑制癌细胞生长已得到证实。这些发现表明，山柰酚可能通过拮抗 ERR 活性发挥其抗癌作用。
