Amjad Elham, Sokouti Babak, Asnaashari Solmaz
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer Cell Int. 2022 Aug 20;22(1):260. doi: 10.1186/s12935-022-02673-0.
It has been shown in multiple experimental and biological investigations that kaempferol, an edible flavonoid generated from plants, may be used as an anti-cancer drug and has been shown to have anti-cancer properties. Many signaling pathways are altered in cancer cells, resulting in cell growth inhibition and death in various tumor types. Cancer is a multifaceted illness coordinated by multiple external and internal mechanisms. Natural extracts with the fewest side effects have piqued the attention of researchers in recent years, attempting to create cancer medicines based on them. An extensive array of natural product-derived anti-cancer agents have been examined to find a successful method. Numerous fruits and vegetables have high levels of naturally occurring flavonoid kaempferol, and its pharmacological and biological effects have been studied extensively. Certain forms of cancer are sensitive to kaempferol-mediated anti-cancer activity, although complete research is needed. We have endeavored to concentrate our review on controlling carcinogenic pathways by kaempferol in different malignancies. Aside from its extraordinary ability to modify cell processes, we have also discussed how kaempferol has the potential to be an effective therapy for numerous tumors.
多项实验和生物学研究表明，山奈酚这种源自植物的可食用类黄酮可用作抗癌药物，并已显示出具有抗癌特性。癌细胞中的许多信号通路发生改变，导致多种肿瘤类型的细胞生长受到抑制并死亡。癌症是一种由多种外部和内部机制共同作用的复杂疾病。近年来，副作用最少的天然提取物引起了研究人员的关注，他们试图基于这些提取物开发抗癌药物。人们已经对大量天然产物衍生的抗癌剂进行了研究，以寻找一种成功的方法。许多水果和蔬菜中天然存在的类黄酮山奈酚含量很高，并且对其药理和生物学作用进行了广泛研究。某些形式的癌症对山奈酚介导的抗癌活性敏感，不过仍需要进行全面研究。我们努力将综述重点放在山奈酚对不同恶性肿瘤致癌途径的控制上。除了其改变细胞过程的非凡能力外，我们还讨论了山奈酚如何有可能成为多种肿瘤的有效治疗方法。
